858 results
The principal aim of this study is to elucidate the role of the glycocalyx in the pathogenesis of pre-eclampsia by assessing: - Whether the glycocalyx is affected in pre-eclampsia and is related to its severity.- Whether glycocalyx perturbation is…
The aim of our project is in-depth characterization of the microbiota components both adjacent to and within the mucosa in patients with IBD, by applying novel high-throughput analysis technology in a global description strategy approach.…
In this project we would like to find out whether Sellotape stripped healthy skin can be used as an in vivo model for mechanical skin damage. This would contribute to more knowledge about growth, differentiation, inflammation and mechanical…
Objective: To assess the effect of beer consumption, with a range of alcohol content, on fluid balance after exercise-induced dehydration. Hypothesis: Based on the glucose and electrolyte composition of beer, and the blurred effect of alcohol in the…
Our aim is to determine the effect of APO* on activity and volume of the hippocampus, a core structure of Alzheimer pathology, at a young age. Specifically, we aim 1) to determine the effects of APOE e4 on hippocampal activation in the young general…
We would like to study whether aberrant heparansulfate synthesis in HME subjects leads to impaired glucose metabolism, dyslipidemia and subsequent increased cardiovascular risk as well as impaired adrenal gland function when compared to unaffected…
The aims of this study are the ascertainment, characterization, and longitudinal follow-up of a large cohort of Dutch families segregating Parkinson*s disease, including affected and unaffected first-degree relatives. The cohort will be…
The aim of this study is to compare the integrity of the corticospinal tract and cortical reorganization of shoulder girdle muscle representations in chronic stroke patients with and without GHS as well as healthy controls.
A better understanding of the underlying mechanisms of depression in Parkinson's disease will lead to better diagnoses, treatments, and quality of life.
To identify some of the mechanisms in patients in remission of Cushing*s syndrome that contribute to the persistence of visceral obesity, systemic inflammation, insulin resistance, sarcopenia, a low muscle oxidative capacity and increased risk of…
To establish the incidence and consequences (impairments op body functions, limitations in participation) of traumatic brain injury in children and youth in a region of The Netherlands as well as the incidence of the same symptoms in a group of…
To elucidate the pathogenetic mechanism of endothelial cell activation in DENV infected patients with sickle cell disorder.
Primary:To investigate the presence of disease-specific antimyenteric antibodies and to identify their target-antigen in patients with achalasia.Secondary:- To determine to what extent humoral autoimmunity is the etiological factor in idiopathic…
Study the mechanisms of BAT activity and the effects of BAT acitivity on energy homeostasis.
To investigate the effects of 5 days of one legged knee immobilization with or without daily NMES on quadriceps CSA, lean mass and muscle fiber characteristics.
The primary objective is to find out whether there is enhanced processing of sensory stimuli when people are in pain and to find out whether SCS has influence on the processing of sensory stimuli applied on non painful body parts. We focus on the…
to investigate functional characteristics of immune cells from MS patients, including migratory capacity, inflammasome activity and Breg cell function and compare these to healthy control subjects 2) to assess possible differences with regard to the…
To further investigate the application in a clinical setting we aim to set up a model in which we can investigate the protective effects in an in vitro model, where subjects blood serum is used to transfer the protective effect of RIPC onto cells…
To investigate the underlying mechanisms of gastroesophageal reflux and gastroesophageal reflux symptoms in treated achalasia patients.
Objective of the study:The results of this study will lead to an improved insight in the lifecycle of these cells in health and diseases, and our results will be of importance for more insight in chronic inflammatory diseases particularly CF. For…