231 results
The main aim is to study early neurocognitive functioning and development in very young children with SCD. The secondary aims are to identify determinants (risk and protective factors) and biomarkers of early neurocognitive deficits in SCD and to…
Objective: In this study we propose elucidating the pharmacokinetics of olanzapine in AN patients, to optimize the dosing strategy, to the extent of increasing the efficacy and reducing the risk of side effects. To this end, we will assess the…
(also see: C1. Protocol, page 9, paragraph 2)Primary: Creating a metabolic bio-database with body material of patients with inherited metabolic diseases, combined with clinical data.Secondary: Achieve better participation in national and…
This study consists of the following objections:- To evaluate feasibility, safety, and efficacy of endoscopic DMR Treatment Paradigm 1 (compared to sham)- To evaluate feasibility, safety, and efficacy of re-treatment with DMR at 24 weeks (compared…
Primary: - Examine longitudinal developmental trajectories of structural and functional brain metrics in relation to genetic, clinical, psychological, environmental, and cognitive information in familial high-risk offspring and control children (…
To examine whether the neutrophil immune profile of healthy geriatric volunteers (age > 70 years) differs from the neutrophil immune profile of young healthy volunteers (age 20 to 25 years).
The aim of this randomized controlled trial is to assess the effectiveness of a guided e-health sleep and biological clock intervention on sleep, mental health symptoms (depression and anxiety), functioning, and quality of life in university…
The purpose of this clinical study is the assessment of the safety and effectiveness of the Flex II PFO Occluder in the treatment of subjects 18 years of age or older who have had a cryptogenic stroke due to a presumed paradoxical embolism as…
The goal of the study is to explore the effects on quality of life of an experimental treatment module that attempts to change trauma related attributions and cognitions in patients with remaining PTSD symptoms.
This study has been transitioned to CTIS with ID 2023-510312-40-00 check the CTIS register for the current data. Main objective- to investigate the effect of alfacalcidol on the treatment of secondary hyperparathyroidism in patients after RYGB…
The primary objective of this study is to investigate how the vascular regulation is altered in the maternal as well as placental vasculature of women with pregnancy disorders (preeclampsia, pregnancy-induced hypertension, FGR, preterm birth,…
To assess kidney oxygenation in obese, hyperfiltering adults with T2D before and after bariatric surgery for men and women separately determined by BOLD-MRI
Our primary objective is to investigate whether a personalised, physiotherapy intervention with integrated therapeutic virtual reality (VR) is (cost-)effective at 3 months and 12 months follow-up, compared to usual physiotherapy, in a subgroup of…
This study has been transitioned to CTIS with ID 2023-506385-30-00 check the CTIS register for the current data. Primary Part 1:-To evaluate ORR in participants treated with MK-4280A plus EV (Arm A), MK-7684A plus EV (Arm B), and pembrolizumab plus…
The purpose of this study is to determine if a diet lacking NEAA, with or without being replaced by additional EAA, influences skeletal muscle protein synthesis rates and whole-body metabolism in healthy young men.
To test whether valve surgery plus medical therapy is superior to medical therapy alone for treatment of endocarditis.
- Part I: determine the difference in microcirculatory perfusion between three different prime fluid strategies in patients undergoing elective cardiac surgery with cardiopulmonary bypass.- Part II: To determine the effect of limiting hemodilution…
The primary objectives of this investigation are to evaluate whether pre-acquired Amycard ECGI map-guided LV lead placement (I) improves CRT volumetric response compared to non-guided (empiric) LV lead placement, and (II) reduces the distance to LV…
We aim that by assessing listening effort subjectively with an adaptive categorical listening effort scale (ACALES) we can demonstrate the possibly increased listening effort in tinnitus patients.
The current study investigates the effectiveness of an intervention that focusses on the adaptive emotion regulation strategy cognitive reappraisal for people with EDs in the reduction of anxiety. This intervention will be compared to a control task…