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Fixed hammer toe correction, surgery with or without K-wire stabilisation?

Comparing two method 's of surgical hammer toe correction. Make clear the value of the K-wire.We use questionnaires about function and pain, patient satisfaction, complication registration, position controle of the toe and x-rays to achieve our…

Coronary angiography after cardiac arrest

Aim of the COACT trial is to compare a strategy of immediate coronary angiography followed by percutaneous coronary intervention (PCI) if indicated with delayed coronary angiography in patients presenting at the emergency department after out of…

Physical ExeRcise Following Esophageal Cancer Treatment (PERFECT) Study: a randomized clinical trial

Primary Objective: - To investigate whether a 12-week exercise intervention increases HRQoL in patients after curatively intended EC surgery compared to a usual care control group.Secondary Objective(s): - To investigate whether a 12-week exercise…

A multicenter, randomized, double-blind, parallel group, active-controlled study to evaluate the efficacy and safety of LCZ696 compared to valsartan, on morbidity and mortality in heart failure patients (NYHA Class II-IV) with preserved ejection fraction (CLCZ696D2301)

The primary objective:To compare LCZ696 to valsartan in reducing the rate of the composite endpoint of cardiovascular death andtotal (first and recurrent) heart failure (HF) hospitalizations, in HF patients (NYHA Class II-IV) with preserved EF (LVEF…

BioNIR Ridaforolimus Eluting Coronary Stent System (BioNIR)
European Angiography Study

The BioNIR is non-inferior to the Resolute for the primary angiographic of in-stent late loss at 6 months

A Clinical Randomized Controlled RSA Trial Comparing the Cemented ATTUNE Fixed Bearing Cruciate Retaining Knee System with the Cemented PFC Sigma Fixed Bearing Cruciate Retaining Knee System

The objective of this study is to accurately assess and compare migration, clinical and radiological outcome and patient reported outcomes of two TKR prostheses: the Cemented ATTUNE Fixed Bearing Cruciate Retaining Knee System and the Cemented PFC…

A Multicenter, Randomized, Double-Blind Study to Evaluate Higher Versus Standard Adalimumab Dosing Regimens for Induction and Maintenance Therapy in Subjects with Moderately to Severely Active Crohn's Disease and Evidence of Mucosal Ulceration.

The objective of Study M14-115 is to evaluate efficacy and safety of higher induction and maintenance dosing regimens in subjects with moderately to severely active Crohn's disease.

The clinical prognostic value of amyloid imaging with [18F]AV-45 in a subjects with subjective complaints

Determination of possible Alzheimer pathology in the brain and to follow-up participants over time (by means of another research protocol). In addition, its [18F]-label with a half-life of 110 minutes will enable use in hospitals without an on-site…

A Phase 1/3, Randomised, Parallel-Group, Active-Controlled, Double-Blind Study to
Demonstrate Equivalence of Pharmacokinetics and Noninferiority of Efficacy for
CT-P10 in Comparison With Rituxan, Each Administered in Combination With
Cyclophosphamide, Vincristine, and Prednisone (CVP) in Patients With Advanced
Follicular Lymphoma

The primary objective:To demonstrate that CT-P10 is similar to Rituxan in terms of pharmacokinetics as determined by AUCtau and CmaxSS at Cycle 4 and maximum serum concentration at steady state The secondary objective:Efficacy: the primary endpoints…

BioNIR Ridaforolimus Eluting Coronary Stent System (BioNIR)
In Coronary Stenosis Trial

1) The BioNIR is non-inferior to the Resolute for the primary clinical endpoint of target lesion failure (TLF) (defined as the composite of cardiac death, target vessel-related MI, or ischemia-driven TLR) at 12 months2/ The BioNIR is non-inferior to…

Randomized "all-comer" evaluation of a permanent polymer zotarolimus eluting stent versus a polymer free amphilimus stent

The study objective is to assess the safety and efficacy of the Permanent Polymer Zotarolimus-Eluting Stent Resolute Integrity* to the Polymer Free Amphilimus-Eluting Stent Cre8* compared in an all-comer patient population. 1 month of dual…

Unravelling Targets of Therapy in Bronchial Thermoplasty in Severe Asthma: The TASMA study

AIMTo discover the molecular, cellular and structural airway targets of BT and link these to severe asthma phenotypes and outcome.OBJECTIVES1. To identify molecular and cellular targets of BT therapy and related changes in airway remodelling. 2. To…

The quantitative assessment of Slow Vision

The main goal of this project is to develop and validate a practical method to quantify slow vision. We will develop new tools to measure *perception time* during the assessment of visual acuity.

Pessary or Cerclage to prevent preterm delivery in women with short cervical length with and a history of preterm birth.

To evaluate whether cervical pessary can replace cervical cerclage in women with previous preterm birth and a short cervix or in women with a history of multiple preterm births in terms of effectiveness and costs

A Double-Blind, Randomized, Multicenter Study of Higher Versus Standard Adalimumab Dosing Regimens for Induction and Maintenance Therapy in Subjects with Moderately to Severely Active Ulcerative Colitis

The objective is to evaluate safety and efficacy of higher induction and maintenance dosing regimens in subjects with moderately to severely active Ulcerative Colitis (UC).

A Phase 3 Open Label, Multicenter, Extension Study to Assess the Safety and Efficacy of Recombinant Coagulation Factor VIII (rVIII-SingleChain, CSL627) in Subjects with Severe Hemophilia A

Primary objectives of the study are:• Arm 1 and Arm 3 (PTPs): to characterize the long-term safety profile of rVIII SingleChain with respect to inhibitor development in PTPs.• Arm 2 (PUPs): • To characterize the safety with respect to inhibitor…

Vincristine-induced peripheral neuropathy in children with childhood cancer: comparing one-hour infusions with short-term infusions (the VINCA-study)

This study aims to investigate whether the administration of VCR in children with acute lymphoblastic leukemia, nephroblastoma, low-grade glioma, Hodgkin lymphoma and rhabdomyosarcoma by one-hour infusions, resulting in lower peak plasma…

STOMACH trial: Surgical Technique, Open versus Minimally-invasive gastrectomy After CHemotherapy

Goal of the STOMACH trial (Surgical Technique, Open versus Minimally-invasive gastrectomy After CHemotherapy) is to establish the optimal surgical strategy in the treatment of gastric cancer. A minimally-invasive total gastrectomy will be compared…

A Phase III, multi-center, double-blind, randomized withdrawal study of LCI699 following a 24 week, single-arm, open-label dose titration and treatment period to evaluate the safety and efficacy of LCI699 for the treatment of patients with Cushing*s disease

To assess the efficacy and safety of LCI699 in CD patients

International Study for Treatment of Standard Risk Childhood Relapsed ALL 2010

Primary objectives:- Overall: Improvement of event-free survival (EFS) probabilities in childhood relapsed ALL- Randomization 1: EFS of Arm A (ALL-REZ BFM 2002) versus B (ALLR3) in SR patients- Randomization 2: Influence of epratuzumab on EFS in…