729 results
Main objective: To determine the impact of FDG-PET/CT on decreasing the fraction of patients with cytologically indeterminate thyroid nodules undergoing unbeneficial patient management.
To compare HM to ultrasound guided electric vacuum aspiration (EVA) for removal of placental remnants with respect to the risk of IUA formation, and in terms of efficiency and complications.
We hypothesize that the long-term efficacy of POEM is comparable to the efficacy of laparoscopic Heller myotomy in treatment of patients with symptomatic idiopathic achalasia. The assumption is thus that POEM is non-inferior to laparoscopic Heller…
The primary efficacy objective for this study is as follows:* To evaluate the efficacy of etrolizumab (105 mg subcutaneous [SC] every 4 weeks [Q4W]) compared with infliximab in achieving both clinical response at Week (W) 10, and clinical remission…
This study has been transitioned to CTIS with ID 2024-512657-24-00 check the CTIS register for the current data. Stratum 1:To show that a non total body irradiation (TBI) containing conditioning (Flu/Thio/ivBu) results in a non inferior survival as…
The primary objective of the study is to assess if treatment with veliparib plus carboplatin and paclitaxel results in improved survival compared to Investigator's choice of standard chemotherapy in Lung Subtype Panel (LSP) positive subjects…
The 4D-EEG study aims to elucidate the underlying mechanisms of upper limb functional recovery using high density portableEEG (electroencephalography) methodology as well as clinical measures of motor function. The following questions are addressed:…
The main aim of this study is to examine predictors of (changes in) employment status and work absenteeism in relapsing-remitting MS patients and subjects without a chronic disease over a period of three years
The main objective of this study was to assess whether the proven effective standard treatment for PTSD knowing Imaginary Exposure in PTSD patients with comorbid many symptoms ( such as depression and middelenafhankeliijkheid ) , which allows…
Primary ObjectiveThe primary objective is to evaluate the effectiveness of adding Epanova to statin therapy (with or without ezetimibe) for lowering MACE (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, emergent/elective…
The primary efficacy objective is to assess the incidence of symptomatic recurrent venous thromboembolism.The secondary efficacy objective is to assess the incidence of symptomatic recurrent venous thromboembolism and asymptomatic deterioration on…
The main objective of this study is whether EMDR is an appropriate treatment for women with PTSD after a previous birth. The resulting hypotheses are that at the two follow-up meaurements, in relation to the pretreatment-measurement 1) WITHIN the…
To evaluate the effect of pneumodilatation (PD) on prolonged dysphagia after Toupet or Nissen fundoplication compared to sham dilatation.
Primary objective is to investigate whether secondary deterioration after acute stroke is associated with CSD, infraslow activity, or epileptiform activity. Secondary objectives are (1) to assess the feasibility of continuous full-band EEG to…
More knowledge on immunity to VZV in these patient groups is necessary to be able to design preventive strategies to VZV infections in the future. To reach these goals, the proposed study is divided into two parts. The first part aims to determine…
Quizartinib selectively inhibits survival pathways that block apoptosis by inhibiting FLT3. Quizartinib inhibits proliferation of FLT3-dependent cell lines, and is effective in human leukemia tumor xenograft models of AML. Data from the Phase 1 and…
The ICAN research question is: What is the effectiveness of an intrathoracic compared to a cervical esophagogastric anastomosis after (hybrid) minimally invasive esophagectomy in terms of anastomotic leakage, morbidity, quality of life and costs?
This study has two objectives: (1)To establish the effects of (a) body weight support (b) treadmill speed, and (c) the level of movement support provided by the Lokomat (so called *guidance*), on the neuromuscular control of the lower extremities in…
Primary: To evaluate the efficacy of FF/UMEC/VI to reduce the annual rate of moderate and severe exacerbations compared with dual therapy of FF/VI or UMEC/VI in subjects with COPD. Secondary: Long term safety and other efficacy parameters.
The goal of this study is developing a non-invasive method to test for a specfic allergy using fingermarks.