729 results
The ICAN research question is: What is the effectiveness of an intrathoracic compared to a cervical esophagogastric anastomosis after (hybrid) minimally invasive esophagectomy in terms of anastomotic leakage, morbidity, quality of life and costs?
This study has two objectives: (1)To establish the effects of (a) body weight support (b) treadmill speed, and (c) the level of movement support provided by the Lokomat (so called *guidance*), on the neuromuscular control of the lower extremities in…
Primary goal: Investigate the hypothesis that suture repair of a ruptured vkb, combined with a dynamic intraligamentary stabilization and microfracture of the femoral notch, results in at least equal effectiveness compared with an ACL reconstruction…
Primary: To evaluate the efficacy of FF/UMEC/VI to reduce the annual rate of moderate and severe exacerbations compared with dual therapy of FF/VI or UMEC/VI in subjects with COPD. Secondary: Long term safety and other efficacy parameters.
The primary objective of this study is to evaluate the effectiveness and cost effectiveness of a multimodal rehabilitation program (MRP) in reducing functional disability (measured with the Functional Disability Inventory) for adolescents with…
The goal of this study is developing a non-invasive method to test for a specfic allergy using fingermarks.
• To assess the added predictive value to known clinical predictors of a questionnaire that generates bleeding scores during pregnancy with regards to predicting (major) obstetric haemorrhage. • To describe the associations of haemostasis and…
Primary objective is to investigate whether delineation of the epileptogenic tissue during aECoG-guided surgery guided by HFOs instead of epileptiform spikes, will not lead to a worse outcome with respect to post-operative seizure freedom. Secondary…
To examine whether culprit lesion only percutaneous coronary intervention (PCI) with subsequent staged revascularization is beneficial over immediate multivessel revascularization by PCI for patients with cardiogenic shock complicating acute…
The primary objective of the Phase I portion of the study is the following:* To estimate the maximum tolerated dosing schedule for venetoclax given in combination with R-CHOP or G-CHOP to patients with B-cell NHL, either previously untreated or…
To evaluate the benefits, risks and costs of laparoscopic gastrectomy as an alternative to open gastrectomy (gold standard) as treatment for gastric cancer in a Western population.
To demonstrate the presence of a reduced age specific ovarian reserve status in BRCA mutation carriers by:1. using serum AMH as ovarian reserve status test. 2. using the antral follicle count (AFC) as ovarian reserve test3. using ovarian response to…
Primary Objective: To study arterial vessel wall abnormalities of the intracranial vessels (circle of Willis and its main branches and the moyamoya vessels) in patients with MMV in comparison with age- and sex-matched subjects without known…
Does pulsatile blood flow during cardiopulmonary bypass lead to a reduction in the average increase in postoperative creatinine levels in patients with preoperative renal dysfunction when compared to non-pulsatile blood flow?
The objective of this study is to evaluate the efficacy of oral cabozantinib at adaily dose of 60 mg compared with 140 mg in subjects with progressive,metastatic MTC.
Main objectieve of this study is if EMDR is an effective treatment for women with FoC. Our hypotheses are that in follow-up measurement compared to the pretreatment-measurement 1) WITHIN the treatment group there will be a decrease in the severity…
Primary objective: To assess microbiological, immunological, genetic, clinical, cognitive-behavioral, and epidemiological determinants for development of persisting symptoms in both adult and juvenile Lyme patients, and establish prediction rules *…
To determine which insemination technique in AID (IUI or ICI) is more (cost) effective in terms of ongoing pregnancy leading to a live birth.
To evaluate wheter patients with parodontitis have a more procoagulant, proinflammatory and metabolically disturbed state than patients with a lower periodontal disease burden. Additionally, we want to explore how this relationship is modified by…
The primary objective is to compare the incidence of patient-ventilator-asynchrony during paediatric mechanical ventilation using ventilator waveforms with PVA detected by using the ventilator waveforms in combination with diaphragm and intercostal…