89 results
The proposed experimental pilot study focuses on harm reduction in a specific subpopulation, i.e. in patients with schizophrenia (long-term psychotic disorder) with a suboptimal response to the currently available interventions, smoking a lot of…
The main purpose of this study is to find out whether EMDR is a safe and effective treatment to reduce the symptoms of PTSD in people with mild intellectual disability and borderline intellectual functioning. In addition, it is expected to reduce…
The objective of the current study is to obtain normative data of healthy individuals on brain measures, cognition and blood markers. In addition, we acquire information on childhood trauma, metabolic and immunological parameters in a cohort of…
Primary objectives:* To explore the comparative bioavailability between 12.5 mg of Risperdal® Consta® prepared from a 25 mg dose strength of Risperdal® Consta® EU-sourced, and 12.5 mg of Risperdal® Consta® prepared from a 12.5 mg dose strength…
Empathy is related to quality of life, depression, insight and social functioning and may be an important factor in recovery of people with schizophrenia. Empathy is impaired in schizophrenia, however it is not clear which elements of empathy are…
The aim of this study is the investigate genetic and environmental factors which make a person vulnerable to develop a pychosis and (in patients) affect the progression of a psychosis. A second objective is to investigate the effects of genetic and…
- To establish a model for TDM and calculate the AUC in patients treated with clozapine.- To clinically validate the DBS analysis method for clozapine. - To determine which sample points or combination of sample point(s) gives the best estimate of…
The first goal of this research is to translate the IMI-SR into a valid and reliable Dutch version of this questionnaire (N-IMI-SR). The second objective is to assess whether there is an association between IM and cognition in schizophrenia.
The objective of this project is to assess the applicability of [18F]PK209 for in vivo imaging of the NMDA receptor.
In the last ten years there has been a lot of research to understand persecutory delusions, but these findings had not yet been translated into treatment until Freeman and colleagues (2011). They targeted worry, but showed that rumination has to be…
In preparation for a multicentre randomized controlled trial (RCT) we want to test the psychomotor assertiveness training in a feasibility study. The aim of this study is threefold: 1) We want to evaluate and improve intervention protocol also using…
-to investigate the mass balance following a single oral dose of 14C-labeled research medication-to investigate the pharmacokinetics of total radioactivity in plasma and whole blood-to investigate and quantitate metabolites of the research…
In this study, the binding of JNJ-40411813 to the brain cells and the concentration of JNJ-40411813 in the blood will be studied. Furthermore, the safety and tolerability of JNJ-40411813 will be investigated upon administration of JNJ-40411813,…
Do patients with (recent onset, medicated) psychotic disorder (PDM), in persons at ultra high risk for later psychosis (UHR), in patients with schizophrenia who do not use anti-psychotics anymore (PDUM) report higher levels of trait anxiety (…
Primary ObjectivesThe primary objective is to explore the tolerability, safety and treatment response (maintained/improved efficacy), based on total Positive and Negative Syndrome Scale (PANSS) score, of a transition to flexibly dosed paliperidone…
To determine whether changes in affect of patients with schizophrenia occur after starting clozapine.
The objective is to acquire information about the experiences of people receiving mental health treatment in the Netherlands and to contribute to international knowledge on a topic of importance to all public mental health systems.
The primary objective is to determine the metabolic rate of [18F]-FHBG in the brain of healthy volunteers, for comparison with the metabolic rate that was found in schizophrenic patients in the previous study.
To examine whether mild and subtle induced anxiety or anger increase the extent of the aggressive attitude in stabilized psychotic patients. *Aggression* is operationalised as completing word-stems, a thought experiment, and by a computer game which…
The potential for risperidone to induce hyperprolactinemia in pediatric patients is well known.However, the effects of drug-induced serum prolactin elevations on growth and sexual maturation havenot been as well characterized in pediatric…