777 results
The standard-of-care sentinel lymph node (SLN) procedure in paediatric cancer patients consists of a preoperative intradermal injection with 99mTechnetium-nanocolloid as radiotracer in combination with an intraoperative injection of blue dye for…
Point of care testing with Fcal POCT will reduce substantial the referral rate of children with chronic GI symptoms to the paediatrician.
REE will be assessed using indirect calorimetry. Oxygen consumption (VO₂) and carbon dioxide production (VCO₂) will be measured. The respiratory quotient (RQ) will be derived from VO₂ and VCO₂. Body composition will be determined by…
Primary objective: To determine the prevalence of AKI in critically ill children based on clearance of iohexol.Secondary objectives:1. To determine the prevalence of AKI in critically ill children using serum creatinine, creatinine clearance,…
Primary: To characterize safety and tolerability of each treatment arm tested and identify recommended doses and regimens for future dosesSecondary:* To characterize the pharmacokinetic profile of each investigational drug within each treatment arm…
The aim of this exploratory study is to isolate and store blood samples, fecal samples, biopsies and fresh frozen resection specimen of CD patients undergoing bowel resection, for the identification of biomarkers predicting postoperative CD…
To investigate the potential of atosiban as a treatment for pain caused by endometriosis.
To evaluate early cerebral perfusion changes of the ischemic brain after IVT and/or EVT in relation to progression of infarct core assessed by arterial Spin Labeling perfusion MRI.
The main purpose of this pilot study is to assess the feasibility and potential efficacy of implant retained mandibular advancement device (MAD) therapy on a small scale in edentulous patients with mild to moderate OSA in terms of sleep apnea…
The primary aim of the study is to increase knowledge about the short and medium term effect of an intensive period of (organised) exercise on the level of HbA1c in the blood of diabetics. This can help caregivers in giving lifestyle advice to…
The objective of this study is to investigate if low frequency stimulation with a DRG stimulator effects peripheral blood blow in patients with CRPS and vasomotor disturbances. The secondary goal is to investigate if the frequency with the best…
Neurotransmitter systems, such as dopamine, are influenced by sex hormones (Riccardi et al., 2011); in fact, with respect to sex differences in dopaminergic neurotransmission, it has been suggested that in dopamine regulating genes, sexual…
To obtain blood samples from twenty-one adult hemophilia A patients with and without inhibiting FVIII antibodies for biochemical analyses in order to show the efficacy and determine the potency of recombinant FIX-FIAV treatment using thrombin…
Primary objective: To evaluate the feasibility to detect a change in tumor PD-L1 expression on a 89Zr-atezolizumab PET scan, before and after two carboplatin induction treatments.
The primary objective of the trial is to evaluate the risk versus benefit of denosumab in maintenance setting in patients requiring long-use (>1 year) of denosumab. For that purpose, the treatment schedule with reduced dose density (120mg SC…
To evaluate the feasibility of TBER-guided ultrafiltration (UF) in patients on HD, using an end-of-HD TBER score of +2 SD as the optimal target.
The primary objective is to compare, in healthy subjects, the injection site experience of a single dose of 0.25 mg semaglutide sc, given as the DV3396 product to that of the PDS290 product.
The primary objective of this exploratory study is to show immunologic efficacy of tumor-peptide and tumor lysate-loaded natural DC in mEC patients undergoing chemotherapy. The immune-monitoring will include: a) functional response and dextramer…
To study the influence of longitudinal changes in the intestinal microbiome on fatigue, and disease course of Crohn*s disease patients.
The primary objective is to investigate feasibility (number of successful automated venipunctures) and safety (number of adverse events and adverse device events). Secondary objectives are to determine subject's pain experience, duration of…