354 results
In this study the efficacy of a novel monoclonal antibody on the development of psoriasis in the humanized mouse model will be investigated.This experimental compound will be compared with 2 registered drugs, i.e. Humira en Stelara.
To see if the new drug can prevent development of psoriatic changes in the transplant model of psoriasis
Validation of the DBS sampling method of cyclosporin in TDM practice
Test efficacy of compounds D+E in humanized mouse model of psoriasis.
The primary objective of the study is to evaluate the long term safety of SAR153191 in patients with RA on top of DMARDs. The secondary objective of the study is finding the percentages of patients who reach ACR20, DAS28 and EULAR response overtime.
To determine the efficacy and safety of tocilizumab in the daily clinical practice situation for at least 36 months in comparison to the reported efficacy and safety in clinical trials.There will be a particular focus of the effect of tocilizumab on…
There is no online self management training yet for young adolescents with a rheumatic disease. Primary objective of this study is the feasibility testing of the online self managementtraining Reuma Uitgedaagd! by the young adolescents whom…
to identify high risk groups in need for more specific and appropriate guidance. Also to provide adequate counselling and help.
The primary objective is to study changes in synovial inflammation in serial biopsy samples following the administration of abatacept in patients with active rheumatoid arthritis.The secondary objectives of this study are to (I) assess clinical…
Primary Objective: To investigate the presence of periodontitis in ACPA and or RF positive patients with arthralgia*s.Secondary Objective: to unravel the role of the cellular immune response in ACPA positive persons with arthralgia*s who are at risk…
To evaluate efficacy and accuracy of diagnostic procedure in our NPSLE clinic and to evaluate effects of advised therapy by means of follow-up data
ln this study the effect of 1 novel compound on the development of psoriasis in the humanized mouse model isinvestigated. The efficacy is compared to two registered drugs, namely Infliximab en Tociluzimab.
We would like to know to what extent psoriasis patients develop antibodies against biologics and what the clinical consequences of these antibodies are in routine practice.
1. Standardized reporting of occurrence of metabolic adverse events after treatment with glucocorticoid pulse therapy in chronic rheumatoid arthritis patients (who have exacerbation of disease).2. Determing if metabolic adverse events due to…
Primairy objective:* To assess whether a poor vitamin D status in RRMS patients is negatively associated with cognitive performance in neuropsychological tests (information processing speed and working memory) and with measures of cognitive (dys)…
The primary objective is to study changes in synovial inflammation in serial biopsy samples following the administration of tocilizumab in patients with active RA.The secondary objectives of this study are to:I. Assess clinical response at week 16;…
ln this study the effect of 2 novel compounds on the development of psoriasis in the humanized mouse model is investigated. The efficacy is compared to one registered drug, namely Stelera.
The prevalence of anti-CCP in periodontitis patients.
ln this study effect of 3 novel compounds on the development of psoriasis in the humanized mouse model isinvestigated. The efficacy is compared to one registered drug, namely Remicade(R).
In previous projects a number of compounds were tested that had a positive effect in the transplant model of psoriasis. However, it proved difficult to prepare formulations that were stable enough to use in clinical studies. A new compound (CD07813…