65 results
Aim of the present study is to assess normal values of EGJ distensibility in healthy volunteers.
The objective of this study is to assess the technical feasibility of the EsoFLIP dilation balloon in the treatment of achalasia
Primary Objective: To assess the impact of RYGB on gallbladder function (during a follow-up interval of 1 year). We will assess the fasting volume, the ejection fraction and the residual volume of the gallbladder. In addition, we will compare serum…
Determine the existence of a relation between GER and apnea and their underlying mechanisms, in infants *37 weeks * 12 months.
To evaluate the safety and efficacy of long term stimulation of the lower esophageal sphincter in patients with gastroesophageal reflux disease after sleeve gastrectomy.
To assess the long-term safety, efficacy, and pharmacokinetics of oral lubiprostone 12 or 24 mcg capsules dosed twice daily (BID) when administered orally for 36 weeks in paediatric subjects with functional constipation. Evaluation of lubiprostone…
The objective of this study is to determine user perception of the 2-piece flat skin barrier compared to the current Dansac flat 2-piece barrier, specifically as it relates to barrier adhesion, barrier tack, comfort, leakage, and ease of barrier…
This study had two objectives:1. which factors determine outcome of treatment of children with functional childhood constipation referred to the outpatient clinic of multidisciplinary treatment clinics in the Netherlands;2. which factors can be…
The primary objective of this study is to to relate bio-impedance findings with microscopically measured intercellular spaces inoesophageal epithelium.
The aim of the study is to investigate whether there are differences in esophagogastric junction distensibility, acid entrapment in the hiatal sac and rate of TLESRs in the pre and post-surgery state.
Primary Objective: To determine oral, gastric and duodenal lipid degradation of fat preloads .Secondary Objectives: To study how the oro-gastro-intestinal digestion of these fat preloads relates to: - Colloidal stability. For this we will monitor…
The primary objective is to assess the effect of sleeve gastrectomy on esophageal acid exposure. Other objectives are to assess the effect of sleeve gastrectomy on motility parameters as LES pressure and esophageal peristalsis.
Key objective: the hypothesis that will be tested Our hypothesis is that the decreased oesophageal acid sensitivity is mediated by oesophageal permeability changes. Furthermore we hypothesize that the electrical tissue impedance of oesophageal…
The aim of this study is to assess the number of supragastric belches and reflux episodes before and after speech therapy in GERD patients with troublesome belching symptoms due to an increased number of supragastric belches.
The aim of the present study is to identify genes associated with functional constipation in a homogeneous subgroup of children responding to sacral neuromodulation by performing whole exome sequencing in both children and their parents and to…
Our hypothesis is that the brain processing of rectal sensation is impaired in children with functional fecal incontinence, leading to reduced cerebral activity during rectal distension. We will perform a pilot study using fMRI in combination with…
We aim to investigate the association between reflux episodes and supragastric belches using the technique of combined HRM and impedance monitoring.
The aim of this study is to gain insight in the mechanisms that may be involved in the effects of plant sterol drinks on gastric emptying and gallbladder motility. In order to test this, we compare the different effects of the consumption of a plant…
The main objective of this study is to obtain normal values for high-resolution manometry. The second objective is to investigate the inter- and intra-individual variability of the measured parameters.
The first aim is to identify possible mechanisms which cause nocturnal reflux in obese subjects. Secondary aims are to identify the role of weight reduction on reflux parameters and to identify the relation between anthropometric parameters (BMI and…