90 results
The main objective of this study is to assess the effects of rituximab (RTX) as a rescue therapy for therapy resistant progressive IMID- IP patients. Specifically there is an objective assessment of (1) pulmonary function tests (PFTs) and (2)…
The specific objectives are:1. What is the difference of in vitro CFTR function in CF patients with either mild (compound heterozygote A455E) mutations or severe (homozygote F508del) mutations with mild or severe clinical disease? 2. What is the…
In this study changes in blood acidity, oxygen tension in the blood, carbon dioxide tension in the blood, respiratory rate and tidal volume (reduction) in the first 24 hours after start of ECCO2R are registered and analyzed. Safety variables during…
To validate two less complex techniques, electrical activity of the diaphragm and ultrasound of the diaphragm, compared to the gold standard (transdiaphragmatic pressures) for monitoring diaphragm function and inspiratory effort during assisted MV…
To determine the tacrolimus bioavailability after tacrolimus administration via a rectiole.
zie nederlandse samenvatting
This study aims to investigate the process and outcome of the implementation of a coaching intervention in COPD care in the Friesland province.
pagina 7-8 protocol
To assess the prevalence of BHD among patients with spontaneous sporadic and familial pneumothorax.
To study the efficacy of danazol in patients with pulmonary fibrosis, and to investigate what factors are associated with effective treatment.
Primary Objective* To evaluate the antitumor efficacy of PO single agent CO-1686, as measured by ORR, when administered to patients with EGFR mutated, centrally confirmed T790M positive and T790M negative advanced NSCLC after tumor progression on 1…
Against this background, we aim to describe response to corticosteroid therapy and tapering in a cohort of newly treated pulmonary sarcoidosis patients, using a hand-held spirometer and patient reported complaints. Results of this pilot-study will…
Our longstanding goal is to assess the clinical applicability of EIT in intubated and mechanically ventilated patients. We aim to observe changes in regional lung ventilation during alterations of mechanical ventilation strategies in clinical…
The primary objective is to identify biomarkers measured in donor and recipient blood before lung transplantation which can predict lung graft function after lung transplantation. When the risk of PGD can be predicted, more adequate therapy can be…
Our longstanding goal is to assess the clinical applicability and technical feasibility of EIT in mechanically ventilated critically ill patients with acute lung injury. Our aim is to establish changes in regional lung aeration with EIT during…
In this study we want to objectively measure the effect of Pirfenidone on cough in patients with IPF.
The objective of this study is to determine the agreement between the traditional endo-esophageal balloon method and newly proposed volumetric method of determining lung compliance.
With this study we aim to provide insight in the role of pulmonary RAS in the pathogenesis of ARDS in neonates and children. This study is performed in the context of a comparative study assessing the impact of age on the pulmonary RAS in ARDS. We…
Primary objective:The primary objective is to answer the question: How do COPD patients experience intensive care unit admission because of exacerbation and what is the impact on their quality of life. This study aims to understand the perspective…
To identify and define characteristics of ILD on the pCLE and pOCT image of airway wall mucosa and the alveolar compartment and compare this to HRCT imaging and pathology.