381 results
Measuring tFUS-dependent changes in behaviour (in our target tasks) when targeting deep brain regions [Behavioral Objective]
The aim of the study is to investigate the effect of magnetic resonance (MR) based online adaptive radiotherapy (RT) for treatment of low to intermediate risk localized prostate carcinoma (PCa) on the radiotherapy dose on the prostate and organs at…
1. To validate the existing guidelines with prospective and retrospective data from this cohort by performing an upper endoscopy at baseline, one year after inclusion and subsequently every three years thereafter in order to assess the risk of…
The primary objective of the study is how patients with therapy resistant anxiety or depression evaluate a well-being intervention *living well with a chronic mental health disorder* and if they experience an increase in personal recovery and mental…
The goal of the study is 1) showing that EA, CA and perceived control are not stable but of dynamic nature and interact in predicting social anxiety symptom severity, 2) identifying possible mechanisms of change of CBT (the exact working of which is…
To assess cognitive impairment in participants with highly-active RMS, having participated in the CLARIFY MS trial, at 4 years afterinitial dose of cladribine tabletsTo assess health related quality of life (HRQoL) in participants with highly-…
Part 1: Dose-Escalation Stage (not in The Netherlands)Primary objective:* Safety and tolerability of HBM4003Secondary objectives:* Preliminary anti-tumor activities of HBM4003 in advanced solid tumors* Pharmacokinetics (PK) of HBM4003Other…
The aim of this study is to investigate the extent to which changes are observed in a physically active man, aged around 85 years in 1) PIFMs* size, 2) dynamic balance and 3) foot function during gait after participating in a PIFM strengthening…
Energy- and nutritional requirements in professional female soccer players: The ProSoccer 2.0 Study.
ln the current study we aim to assess the energy requirements and physical activity patterns in professional female soccer players along with their nutritional intake patterns. As such, this study will provide valuable information to optimize the…
The primary aim of this study is to examine the feasibility, usability, and acceptability of the educational care pathway for both patients and healthcare professionals. The secondary aim is to investigate the preliminary effects on patients*…
To characterize the immunological read out, e.g. the immune cell compartments, and antibodies of patients with autoimmune bullous diseases during rituximab treatment and during relapses.
Primary objectives1. To assess the safety of Tam added to Ven. Venetoclax will be dosed at 800 mg once daily. After 2 days of venetoclax, tamoxifen will be orally administrated in a ramp-up phase (2 days 10mg, 2 days 20mg, to a final dose of 40 once…
The primary objective is to test whether rhythmic somatosensory input (vibrotactile stimulation at tremor frequency) reduces tremor power of Parkinson*s tremor, as compared to other vibrotactile stimulation settings (continuous stimulation,…
Primary Objective: Does DBS result in cognitive changes in patients with OCD on the long term? Secondary Objective(s): Does DBS result in personality changes in patients with OCD on the long term?Are certain cognitive profiles associated with…
To assess the utility and diagnostic accuracy of capillary glucose samples (using the Roche Accu-Chek Inform II point-of-care testing device) compared with venous glucose samples with laboratory determination as the gold standard. To determine the…
The primary objective is to compare the glucose curve with the OGTT, as a screening test for GDM.The secondary objective is to see if GDM treated after screening either with the glucose curve or with the OGTT, can predict perinatal complications and…
To assess the efficacy and safety of vaccination against COVID-19 in patients with CKD4/5, patients on dialysis, and kidney transplant recipients as compared to controls
Primary Objectives- To determine the optimal dose of the VEGF-A targeting NIRF tracer bevacizumab-IRDye800CW for an adequate tumor-to-background ratio (TBR) in PTC/FTC/HTC/PDTC lymph node metastases.Secondary Objectives- To evaluate the feasibility…
To investigate the effect of whey and casein ratio of IFT on intragastric behavior, gastric emptying and postprandial plasma metabolome
In this study we will investigate how quickly and to what extent ralmitaront is absorbed, transported, and eliminated from the body (this is called pharmacokinetics). Ralmitaront is radioactively labelled with carbon 14 (14C). In this way…