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A Multicenter randomized trial, comparing a 25G EUS Fine Needle Aspiration (FNA) device with a 20G EUS ProCore Fine Needle Biopsy (FNB) device

To compare the performance and diagnostic accuracy of two EUS-guided tissue acquisition devices; a 25G Echotip Ultra Fine Needle Aspiration (FNA) device and a new, more flexible, 20G Echotip ProCore Fine Needle Biopsy (FNB) device.

Synovial tissue analysis of factors related to bone-destruction and bone-production in patients with knee arthritis

Aim of this study is to obtain synovial tissue and synovial fluid, from 80 patients with non-septic, inflammatory knee arthritis undergoing routine arthroscopy of the knee and analyze inflammatory factors influencing osteoclast and osteoblast…

Brain specific proteins in tissue macrophages in acute ischemic stroke. Association with functional and radiological outcome; a pilot study.

To investigate whether the amount of TiMas containing brain specific proteins, correlates with functional outcome and infarct size in patients with acute ischemic stroke. And, to study the kinetics of the tissue macrophages and to compare these data…

Screening of Hindustani people for risk factors of cardiovascular disease

The primary objective of this study is to assess the CV risk profile of Hindustanis without known diabetes mellitus (DM), hypertension, dyslipidemia or CV disease and evaluate the 10-year CV risk according to the Framingham risk score. Secondary…

Registry of the treatment of primary insufficiency of the great saphenous vein with a diameter >/= 12 mm, antero-lateral branches, or great saphenous vein insufficiency below the knee with mechano-chemical endovenous ablation (MOCA)

The goal of this registry study is to provide insight in the safety and efficacy of treatment with MOCA for primary insufficiency of the GSV with a diameter >/=12mm, insufficient antero-lateral branches (<12 mm) and insifficincy of the…

Time of onset and time of offset of sacral neuromodulation effect.

The main objective is to evaluate the average time span within which *time of onset* and *time of offset* occurs in patients with overactive bladder syndrome or non-obstructive urinary retention who respond to SNM.

A post market clinical follow-up study with the artificial hip joint CBH Stem, with initial RSA analysis

To document the initial stabilty of the CBH stem with radiostereometric analysis in the first 30 patients, and to perform a clinical follow up of at least 150 patient treated with this implant to document the outcome.

An Open-label, Phase 2 Study of ACP-196 in Subjects
with Waldenström Macroglobulinemia

The purpose of this study is to evaluate the safety, pharmacokinetics, pharmacodynamics and activity of ACP-196 in treating subjects with Waldenström disease.

Medtronic PERIcardial SurGical AOrtic Valve ReplacemeNt Pivotal Trial (PERIGON) Long-term Follow-Up.
A multi-center, non-randomized trial to determine the safety and effectiveness of the Model 400 aortic valve bioprosthesis in patients with aortic valve disease.

To evaluate the safety and effectiveness of the Model 400 Aortic Valve Bioprosthesis. LTFU:To evaluate the long-term safety and effectiveness of the Avalus Bioprosthesis.

Effectiveness of neurolysis versus neurectomy of the lateral femoral cutaneous nerve (LFCN) in the treatment of meralgia paresthetica.

The goal of the stomp trial will be to investigate the effectiveness of both the neurolysis and neurectomy procedure in patients with persistent symptoms of meralgia paresthetica. In addition, in this trial we want to determine to what extend…