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Costs of Implant-supported Over-Dentures (IOD) can be halved using a digital workflow

Our goal is to manufacture a 3D-IOD which is designed digitally, and subsequently 3D-printed. Such 3D-IOD, can be made cheaper, faster and more patient friendly. To prove such a statement, patients should at least be even satisfied about their 3D-…

Becker Muscular Dystrophy: analysis of diversity in disease severity

1. To investigate the possible relationship between amount of dystrophin expression and clinical severity of BMD2. To investigate the relationship between specific BMD-gene mutations and clinical severity of BMD3. To investigate possible other…

Euthanasia and physician assisted suicide in Huntington's disease, an investigation amongst patients and physicians.

To investigate the opinion of physicians about euthanasia and/or pysician assisted suicide in HD patients, in The Netherlands and surrounding European countries.To investigate the opinion of patients about euthanasia and/or pysician assisted suicide…

Inflammatory Bowel Disease Tracker

The primary objective of this study is to identify biomarker fingerprints in patients with ulcerative colitis (UC) and Crohn*s disease (CD, that can indicate that an exacerbation has begun, although the patient still feels well. Ultimately, the…

Implantation of an auditory brainstem implant for the treatment of incapacitating unilateral tinnitus

To evaluate the efficacy of an ABI for the suppression of unilateral, intractable tinnitus and to establish the safety of the ABI for this new indication.

Short and long term effects of clinical DBT-PE for patients with severe posttraumatic stress disorder and co-morbid psychopathology

The current study aims to determine the effect of a 12-week residential DBT-PE program on a range of different outcomes, including the severity of PTSD, dissociation, personality disorders, and social functioning; The study also aims to predict…

Efficacy of vaccine responses against SARS-Cov-2 in patients with giant cell arteritis and polymyalgia rheumatica (GPSVAC)

The main objective of this study is to assess effectiveness of the COVID-19 vaccinations, based on humoral (anti-coronavirus antibody) immunity, in GCA and PMR patients. Other objectives are assessing antigen-specific cellular (T-cell) immune…

Use of physiology to evaluate procedural result after PCI CTO

Primary objective: -To assess the predictive value of post-PCI RFR (resting full-cycle ratio) and FFR (fractional flow reserve) with regard to SSR (suboptimal stent result) in CTO (chronic total occlusion) patients. Secondary objectives:- To assess…

QuantiFERON-SARS-CoV-2: performance of an Interferon-Gamma Release Assay for COVID-19 before and after vaccination against SARS-CoV-2

The study is intended to determine the performance of a QuantiFERON SARS-CoV-2 test that QIAGEN will bring to the diagnostic market. The proposed study will contribute to establishing the diagnostic parameters such as specificity, sensitivity and…

An open label, multi-center roll-over study to assess long-term effect in pediatric patients treated with Tafinlar (dabrafenib) and/or Mekinist (trametinib)

This study has been transitioned to CTIS with ID 2023-509276-42-00 check the CTIS register for the current data. Primary:To assess the long-term safety of treatment with dabrafenib, trametinib or the combination.Secondary:To assess the long-term…

Neural correlates of trauma-focused psychotherapy in PTSD: A longitudinal fMRI investigation

The current study*s primary aim is to test how trauma-focused therapy affects PTSD symptom-specific neural activity, and investigate neural markers that may predict treatment response to trauma-focused exposure. Furthermore, it is expected that…

EMDR Flash Forward as an intervention on the mental images of worst case scenarios in paranoid delusions

Primary Objective: Investigate whether EMDR Flash Forward is an effective intervention to process the mental images of worst case scenarios that occur in paranoid delusions, in order to decreases the preoccupation with the delusion.Secondary…

MyLeg P1: The functional evaluation of a ankle prosthesis prototype for osseointegrated transfemural amputees

To evaluate the performance of the newly-developed prosthesis (prototype) during walking in people with a transfemoral osseointegration implant. This will be done using lab-based measurement, evaluating metabolic cost, walking capacity, gait pattern…

rotational ThROmboelastometry in Patients at risk for disseminated Intravascular Coagulation*

The aim of this study is twofold: 1) to measure ROTEM profiles in patients at risk for DIC to determine cut off values of ROTEM corresponding to the currently used International Society for Thrombosis and Haemostasis (ISTH) DIC scores, as well as to…

Trauma-focused exposure therapy for posttraumatic stress disorder in patients with eating disorders

The current study is an initial evaluation of the feasibility and effects of exposure therapy in those suffering from ED and comorbid PTSD.

Early Maladaptive Schema*s and modes in anorexia nervosa compared to bulimia nervosa/binge eating disorder*

This study investigates Early Maladaptive Schemas (EMS) and modes in function of eating disorder subtype and behaviour, such as vomiting, laxative misuse, restricting, frequency of binges and BMI.

An open, prospective, multicenter investigation to evaluate the clinical outcome of PrimeTaper
EV implant in extraction sockets and healed ridges - A 5 year follow-up

1. Primary objectiveThe primary objective of this clinical investigation is to evaluate implant survival rate 1 year afterpermanent restoration (PR), i.e. implant in place 1 year after PR, Yes/No.2. Secondary objectivesThe secondary objectives are…

Balloon Expandable vs. Self Expanding Transcatheter Valve for Degenerated Bioprosthesis

To compare safety and efficacy of EVOLUT R/Pro vs. SAPIEN3 Ultra for the treatment of a failing surgical aortic bioprosthesis

Immune profiling of stage III non-small cell lung cancer patients treated with concurrent chemoradiation and adjuvant durvalumab: A prospective observational phase II trial

Primary Objective: To identify immune changes between baseline, one week of radiotherapy, end of radiotherapy and three months of durvalumab- Identification of differentially expressed proteins at all time points- Identification of differentially…

Effect of Automated Closed-loop Ventilation versus Conventional Ventilation on Duration and Quality of Ventilation (*ACTiVE*) -a randomized clinical trial in intensive care unit patients

To compare automated closed-loop ventilation (INTELLiVENT-ASV) to conventional, non-automated ventilation in patients in the ICU.