13 results
1. To investigate the possible relationship between amount of dystrophin expression and clinical severity of BMD2. To investigate the relationship between specific BMD-gene mutations and clinical severity of BMD3. To investigate possible other…
The primary objective of this study is to identify biomarker fingerprints in patients with ulcerative colitis (UC) and Crohn*s disease (CD, that can indicate that an exacerbation has begun, although the patient still feels well. Ultimately, the…
The main objective of this study is to assess effectiveness of the COVID-19 vaccinations, based on humoral (anti-coronavirus antibody) immunity, in GCA and PMR patients. Other objectives are assessing antigen-specific cellular (T-cell) immune…
This study investigates Early Maladaptive Schemas (EMS) and modes in function of eating disorder subtype and behaviour, such as vomiting, laxative misuse, restricting, frequency of binges and BMI.
To investigate whether high perceived stress is associated with inflammatory reprogramming of innate immune cells and their bone marrow progenitors, and with increased arterial wall inflammation, in subjects with an increased CVD risk.
Aim of the studyWe intend to study in detail the different aspects of B cell biology in the auto-immune diseases outlined above. With the sample material obtained from patients (see below), we will be able to analyze (auto-reactive) B cells and…
Objectives of phase 7 of the ABCD-study are:(i) to follow-up on growth trajectories during childhood/adolescence and identify lifestyle and environmental factors that influence thesetrajectories;(ii) to follow-up on cardiometabolic health during…
To assess the effect of dietary lipids on the small intestinal microbiome in humans (proof-of-concept), the primary objective is to measure production of microbiota-derived lipid metabolites in the human small intestine after consumption of a high-…
Primary objectives are displayed here.Part 1: Establish the effect of early life cardiovascular risk factors on pre-clinical atherosclerosis in adolescents.Part 2: Identify the impact of diminished early life lung function on lung function during…
Trend analyses Of Patient-Specific respiratory Physiologal INteractions for weaning decision support
The primary objective of this study is to investigate the relation between, on the one hand, 1) the balance between the respiratory system mechanics and muscle dynamics, and 2) the balance between the pressure support level and respiratory drive,…
The objective of this study is to investigate which pathways explain the association between social jetlag, insulin sensitivity and glucose metabolism in people with prediabetes with and without social jetlag.
Primary Objective: To compare nasal CD8+ T cell frequency between young adults and frail older adults.Secondary Objective(s): 1. In depth profiling of T cells in nose and blood of young adults and older adults with and without frailty.2. Assess the…
The aim of this research project is to investigate whether time-related trajectories of intrinsic capacity can predict maintenance of robustness (healthy ageing) or the onset of frailty in persons aged 55 to 75 over a period of 10 years. In the long…