80 results
Primary:To understand the relationship between novel risk markers (based on the following) and clinical outcome. Secondary:Developing a score from the predictive model that can be used to assess risk given a patient*s combination of risk factors.
The main objective of this study is to characterize the pathogenic B cells and the auto-antibodies that are responsible for causing the myasthenic or pemphigus syndromes. The secondary objective is to generate recombinant antibodies based on the…
To explore the feasibility and opportunities for new imaging procedures, of relevance of Amsterdam UMC prioritized areas, that a ultra-high sensitivity total body PET-CT system can offer for improving diagnosis and dose reduction.The protocol…
To study the direct effects of long-term intermittent fasting on immune cell populations in the blood, combined with analyses of systemic metabolic fitness and inflammatory activation of leukocytes.
Primary objectives:To prospectively assess longitudinal changes in Proteolipid Protein 1 (PLP1) and additional disease-related biomarkers in cerebral spinal fluid (CSF) and blood and evaluate their utility in support of the development of therapies…
Establishing efficacy and safety of the electrodes and implantable pulse generators (IPGs), which are used for deep brain stimulation (DBS) in patients with obsessive-compulsive disorder (OCD).
The goal of the present study is to evaluate whether voice or capnometry, alone or in combination with other (non-invasive) biomarkers, can be used to detect emphysema predominant COPD phenotype (>=25% emphysematous lung tissue).
To optimize (early) diagnosis and risk-stratification of (early) cardiomyopathy phenotypes and to create a better understanding of underlying pathophysiological processes.
The aim of this study is to assess the efficacy of MR-HIFU as a treatment modality for desmoid-type fibromatosis (DTF).
Primary Objective:To establish the maximum tolerated healthy liver-absorbed dose of 166Ho-microspheres in patients with HCC who receive RL as a bridge to resection.Secondary Objective(s): 1) To establish dose-response relationships between:a. The…
The purpose of the study is to test the feasibility of image-guided navigation during robot-assisted sentinel node dissection.
Primary objective: 1. To identify the components in human milk (e.g. nutrients, oligosaccharides, fatty acids and (pathogen specific) immunoglobulins) that have a protective effect against respiratory tract infections during the first year of life.…
Primary Objective: to develop and evaluate a machine learning (ML) prediction model of brain injury in neonates at high-risk for CP to predict motor, behavioral, and cognitive outcome more accurately.This aim will be achieved by: developing and…
objective is to assess feasibility, tolerability and efficacy of aiTBS in patients with bipolar depression (BPD) and negative symptoms of schizophrenia (NSS).
Primary Objective:The primary objective of this study is to prospectively validate a novel intestinal ultrasound (IUS) Crohn*s disease (CD) activity index and component items, correlating CD activity and responsiveness to therapy as evaluated by IUS…
Primary objective: To assess the feasibility and adherence of home-based monitoring of multiple aspects of disease progression in patients with ALS in order to develop a widely supported set of reliable digital parameters to capture data, collected…
This study investigates how well the combination of the two drugs, zibotentan and dapagliflozin, works for the treatment of chronic kidney disease in patients. We compare the effect of zibotentan and dapagliflozin with the effect of a placebo. The…
The main objective of this study is to evaluate the clinical effects of SCS on the number and intensity of VSA attacks. Secondary objective is to objectivate the effects of SCS on coronary spasms during the provocative acetylcholine test, and assess…
Primary Objective: To investigate longitudinal variation of blood-based biomarkers, their integration with disease severity, comorbidities, their association with standard care and characterization of adequate and inadequate responders to standard…
The purpose of the study is to systematically document the signs and symptoms of sexual abuse in infants and very young children and the short-, medium-, and long-term effects of the abuse, including the effects of the persistence of pornographic…