80 results
The primary objective is to explore the effect on Donning and Doffing of REACTION and their subsystems (ABLE REGAIN and GABLE CORE) in individuals with neurological disorders. The secondary goals include: 1. To explore the effect of REACTION and…
The primary objectives are to: (a) identify the key pleasures, challenges and stressors that nurses face, to be able in the future to explore potential opportunities for professional development and support; (b) to ascertain the primary threats to…
This study*s research objective is to investigate the validity of BT measurement through skin temperature and skin heat flux measurement by the Corsano CardioWatch 287-2 against invasive rectal body temperature monitoring devices in a clinical…
The objective of this study is to investigate the role of platelets in fibrosis and inflammation by examining their effects on key cellular processes. Specifically, we aim to:1. Determine whether activated platelet stimulation induces fibrosis…
Our primary objective is to collect normative reference values in typically healthy developing children, aged 0 - 18 years, for EEG in combination with ERP and eyetracking, and OCT measurements (For details see also paragraph 5.1).
Primary Objective: To evaluate the feasibility and acceptability of AET in the inpatient treatment of AN through qualitative feedback from patients and clinicians.Secondary Objective(s): To identify autonomy-related interventions currently already…
The aim of this study is to determine whether this smart wristband can actually support patients and their parents in managing the consequences of hypothalamic dysfunction. We will investigate what kind of support patients, parents, or caregivers…
The overarching objectives of this proposal are: 1) To evaluate the effect of noradrenergic modulation on type I potentials in wakefulness (vertex potentials), and NREM sleep (vertex sharp waves, K-complexes) and on dreaming in NREM sleep; 2) To…
To investigate the change in exercise physiology during daily activities after EBV treatment.
In this study, we aim to improve the genetic diagnosis of patients with genetic renal tubulopathy-related disorders. We hypothesize that a higher diagnostic yield can be obtained by genetic re-screening of patients using the updated renal gene panel…
To study the feasibility of invasive exercise right heart catheterization in adult patients with repaired tetralogy of Fallot and severe PR and to study exercise parameters in volume loaded RV in repaired tetralogy of Fallot which could help to…
To identify and synthesise patient-specific neoantigen peptides from residual material of resected pancreatic cancer tissue, from the organoids established from the resected pancreatic cancer tissue (MEC-2021-0325) and from peripheral blood.
To investigate whether TLND can be safely omitted in patients with macroscopic resectable stage III (B/C/D) melanoma achieving an MPR within the ILN upon neoadjuvant treatment with nivolumab in combination with ipilimumab.
We want to identify which patients will develop arthritis with the long-term and ambitious aim of trying to prevent the development of arthritis before it occurs. As many (most) participants will not develop arthritis, we are also studying the…
The goal of the current study is to evaluate both the feasibility and validity of the Corival ALT prototype for exercise testing in patients with lower limb deficits.
The aim of this study is to characterize the internal 1 µm polystyrene microplastic (PS-MP) exposure in various human tissues in healthy volunteers. For this, the uptake and excretion of a single microdose of 1 µm [14C]-labelled PS-MP is…
The main objective of the study is to investigate the effect of inclusion in the LLA on E33 notifications. Secondary objectives include investigating the effect of inclusion in the LLA on criminal behaviour (arrests, recidivism and risk of…
The objective of this CPS is to establish the clinical performance of F1CDx as a companion diagnostic (CDx) for AZD0022 in patients with NSCLC, CRC, or PDAC with a KRASG12D mutation. This CPSP will be executed in combination with the clinical trial…
The main (primary) objective is to study the influence of sex on the pharmacokinetics (PK) of metoprolol in patients after CABG with heart valve surgery and patients with a STEMI/NSTEMI who are prescribed a standard dosage of metoprolol as part of…
Primary Objective: To determine how exposure to +5Gz forces affects small airway function when breathing ambient air (21% oxygen) and oxygen enriched air (60% oxygen) , without the breathing component of the AGSMSecondary Objective: To explore the…