30 results
The aim of this project is to evaluate the clinical value of biomarkers in adult patients with congenital heart disease, in particular:1) quantify biomarkers of neurohormonal activity as NTproBNP, endotheline-1 and of immunological activity as CRP,…
The primary objective is to investigate the determinants of aortic root deformation occurring >= 3 months after successful ASO implantation in adult patients with an atrial septal defect.
The aim of this study is to investigate the relationship between atrial septal defects and airway responsiveness before and after percutaneous closure.
The aim of this study is to identify genetic defects underlying CHD and aortic aneurysms. This will provide insight in the aetiology and heredity of these diseases.
To phenotype and genotype the population of patients with IVF in our cohort, and to find alternative diagnoses as a cause of the event of VF.
Our primary objective is to identify the patients with congenital heart defects in whom CHD7 mutation detection is needed. Secondly we want to identify the co-existing medical problems in children with a congenital heart defect due to a CHD7…
The main goal of this study is to examine the clinical applicability of the Monica AN24*, for the use of this device in the LUMC for prolonged CTG-registrations in high risk pregnancies and particularly in monitoring fetal cardiac arrhythmias. The…
The objective of this study is to determine the frequency of previously undiagnosed SCN5A mutations leading to sudden death in temporal association with vaccination in The Netherlands.
The primary objective is to evaluate the presence of brain damage (defined by white matter lesions (WMLs) or cerebral atrophy or deviations at neuropsychological examination (NPE)) among adults with tetralogy of Fallot (TOF). The secondary objective…
1) To electrophysiologially characterise a selected, large cohort of patients prone to malignant ventricular arrhythmias (ICD recipients)2) To exactly quantitate outcome by total mortality as well as malignant arrhythmia risk through number of…
The objective of the present study is the evaluation of ventricular function in patients with congenital heart defects by means of newly developed echocardiographic techniques as tissue doppler and speckle traking stran rate echocardiography. Since…
We aim to identify sequence variations within pedigrees and determine how these may result in CVD by studying the effect on cell phenotype.
To study whether inflammmation plays a role in patients with RV disease, and can be detected with Gallium-67 scintigraphy
With iPS-CM we want to elucidate the effect of mutations on cellular and molecular level. With this knowledge it will be possible to understand the mechanism underlying heterogeneity in various arrhythmia syndromes, which will open the door for…
We aim to create a large cohort of patients with early-onset CAD to study sequence variations resulting in CVD. Initially, by validating sequence variations in candidate genes and loci found by our PAS pedigrees work, GWAS studies and Cardiochip…
Identification of genes that are involved in congenital heart defects.
- Identify key factors of the cardiac transcriptome in patients with cardiac malformations- Identify the transcriptional regulatory interactions underlying the cardiac transcriptome- Bioinformatically map and analyse the cardiac regulatory network…
Primary Objective: Further delineation of the natural history and phenotype/genotype relation of vEDS pateints with a heterozygous pathogenic variant in the COL3A1 gene. Secondary Objectives: 1. reasons for referral for genetic analysis; 2. all…
To quantify the role of different abnormal loading conditions on atrial and ventricular electropathology in paediatric patients with CHD.
Primary Objective:1) Assess different LV loading mechanisms in Barlow's Disease (BD) versus Fibroelastic deficiency (FED), including transvalvular mitral regurgitant and prolapse volume, both with echocardiography and cardiac magnetic resonance…