35 results
Primary objective:We hypothesize that genetic variability influences mitotane pharmacokinetics. Therefore our aim is to explore the inter-individual differences in genes coding for drug metabolizing enzymes in patients treated with mitotane and to…
The aim of this study is to determine novel (bio)markers that show a stronger correlation with signs of over- and under-treatment than the conventional adrenal steroid profile in children with CAH.
- assessment of age dependent reference values (ages 20 - 70 yrs) for plasma renin (activity and concentration), serum aldosterone and 24h urinary aldosterone (free and metabolites) during a regular diet and after a 3 day oral salt loading test-…
A core part of the scientific efforts of ENS@T researchers bases on the establishment of a common registry and associated collection of biomaterials. Patients with adrenal tumours prospectively included in the ENS@T registry will be asked to provide…
1. Examen if the outcome of the 1 mg Overnight Dexamethasone suppression test is influenced by the use of oral contraception.2. Examen how many weeks after ceasing the use of orale contraception the 1 mg Overnight Dexamethason suppression test is…
Comparison of the salivary cortisol response after a standardized exercise test between prepubertal heathy children and children with asthma.
The objective of the study is to determine whether 11C-metomidate PET can differentiate between BAH and APA./PAH
The main objective of this study is to construct a population-pharmacokinetic model, in order to evaluate the influence of patient characteristics on the pharmacokinetics of mitotane in patients treated with this oral therapy.
1 To evaluate the feasibility to measure cortisol levels in hair in healthy children and children with asthma who use inhaled corticosteroids2 To evaluate differences in cortisol levels in hair in healthy children and children with asthma who use…
The objective of the study is to determine whether it is necessary to take the blood pressure lowering medication (β-blocker, ACE-inhibitors or diuretics) of a patient into account prior to blood sampling for pheochromocytoma diagnostics. Therefore…
We hypothesize that cardiovascular risk factors may already be present during childhood in CAH patients. Therefore, we will perform a cross-sectional study in CAH patients aged 1-16 years evaluating blood pressure, lipid profile, insulin sensitivity…
Evaluate the effect of topical steroids on salivary cortisol levels, and assess the correlation between salivary cortisol levels, symptoms of asthma, and lungfunction in children with asthma and/or rhinitis
With a standardized approach in a population with difficult to treat hypertension we want to explore how frequenty PHA is a cause of hypertension and what the test characteristics of the aldosterone-renin ratio are. Additionally we want to…
Exploring the incidence of fatigue after sarcoidosis, its severity and nature. Next we will try to associate fatigue with capacity to produce pro- and anti-inflammatory cytokines.Our secondary objective is testing the activity of the HPA-axis, the…
To evaluate if a standardized running test will elicit an increase in salivary cortisol levels in healthy prepubertal children
1. Study of the incidence of TART in male CAH children in a multicentre setting 2. Detection of predisposing factors for tumour growth. 3. Evaluating of gonadal function in male CAH children with TART
In this pilot study we want to determine if a standardized cyclic ergometer test result sin a measurable and reproducible cortisol response.
To investigate cortisol and ACTH rhythm (frequency, amplitude and regularity of cortisol and ACTH secretory pulses) in patients with SCS and bilateral adrenal involvement.
To study the variability of the lateralisation of the aldosterone/cortisol ratio*s when 3 instead of 1 sample is obtained and to study whether instantaneous measurement of cortisol during the procedure will prove to be advantageous.
In this study we want to investigate long-term follow-up of patients with PA. The outcome will be analyzed based on whether a decision to treat was guided by CT/MRI or AVS or both.