51 results
To document cardiac function before and after treatment of CS.
The objective of the study is to improve medical treatment of Cushing's disease by combining partially independent medical therapies which act through differential mechanisms. Given the high affinity of SOM230 to sst5 and considering the facts…
Primary objectivesTo evaluate the prevalence, and incidence in yearly intervals, of pituitary insufficiency after cranial irradiation or total body irradiation at long-term follow-up. Secondary objectiveTo evaluate the impact of cranial irradiation…
To evaluate whether GH substitution in patients with an isolated GHD after TBI could reverse the severity of symptoms which characterize GHD.
Aim of the study is to study the influence of GH receptor polymorfisms on the effects of growth hormone substitution in aduts with GH deficiency.
Comparing the reliability of a dietary-protein test with conventional Growth Hormone Stimulation Tests.
To identify risk factors that might contribute to the development of post-traumatic HHD in children in order to reduce the lag-time between onset and diagnosis for future patients. To investigate the level of functioning and the quality of life of…
(1) To establish the pharmacokinetic profile of clonidine following oral administration in children with suspected GH deficiency. (2) To relate the pharmacokinetics of clonidine to the observed expected (GH-response, cortisol response, depth and…
To study the prevalence of hypopituitarism and osteoporosis in patients 5 tot 10 years after severe traumatic brain injury
To assess the efficacy of the co-administration of lanreotide Autogel 120 mg(administered via deep sub-cutaneous injections every 28 days) and pegvisomant(administered at 40 to 120 mg per week via sub-cutaneous injection given once ortwice a week)…
The purpose of this study, is to evaluate the efficacy and safety of pasireotide alone or in combination with cabergoline in patients with Cushing*s disease as measured by the proportion of patients achieving normal UFC at the end of the study…
This is a protocol aimed at standardizing clinical care and the diagnostic approach in a carrier of a pathogenic IGSF1 mutation referred for hormonal analysis to the outpatient clinic.
Research question:1. Do patients exhibit disturbances of sleep duration or circadian locomotor rhythmicity before surgery? 2. Do these variables change after surgery?
We aim to investigate whether copeptin can be used as an early postoperative marker for development of DI. We will measure copeptin levels in patients just prior to and following transsphenoidal surgery to be able to investigate whether copeptin…
We aim to further study the characteristics of joint disease in acromegaly and its progression, in order to improve care for this patient group and to get insight into the pathogenesis of osteophytes and cartilage hypertrophy in acromegaly and in…
• To assess the prevalence of short stature, in combination with an aberrant IGF-1 in combination with IGF-BP3 in the entire cohort of childhood cancer survivors and the therapy related risk factors.• To assess the distribution of IGF-1 and IGF-BP3…
The primary objective of this prospective international multicenter diagnostic study is the comparison of the diagnostic accuracy between copeptin measurement after arginine-stimulation (CAS) and the current best diagnostic test copeptin measurement…
The primary objective of this study is to determine the feasibility of intraoperative fluorescence imaging detection of PitNET tissue during TSS using the VEGF-targeting optical agent bevacizumab-800CW in tumors with a Knosp grade of 3 or 4.…
To evaluate the effects of GH, after final height is reached, on weight, body composition, psychosocial functioning, carbohydrate metabolism and serum lipids. To find an optimal dose growth hormone for adults with PWS. We aimed to stabilize the body…