Search for a trial

Explorative study on the impact of tea ingestion on forearm resistance artery endothelial function

To examine the acute impact of tea ingestion on forearm resistance artery endothelial function in middle-aged subjects

Comparison of the effects of atropine on haemodynamics and tissue oxygenation in anaesthesia with propofol and sufentanil versus propofol and remifentanil.

To investigate if there is a clinically important different effect of atropine on haemodynamic variables, tissue oxygenation or microcirculation during anaesthesia with either sufentanil and propofol or with remifentanil and propofol.

Active smoking and bronchodilator treatment in patients with chronic obstructive pulmonary disease (COPD): a hazardous combination in causing cardiovascular disease?

The aim of the study is to demonstrate a basic mechanism that supports our hypothesis: Does increased respiratory function after administration of a bronchodilator in patients with COPD lead to elevated pulmonary retention of the harmful compounds…

Does atorvastatin reduce ischemia-reperfusion injury in humans in-vivo?

To study the impact of 3 day exposure to atorvastatin 80mg on Annexin A5 targeting after ischemic exercise in the non-dominant forearm.

A randomized, double blind, crossover, placebo controlled class-room experiment to assess the pharmacodynamics and pharmacokinetics of metoprolol in healthy volunteers with different polymorphism of CYP2D6

Primary Objective• To educate students about the full life cycle of clinical trials including study set-up, design, execution, analysis and reporting• To explore the influence of CYP2D6 polymorphism on the pharmacodynamics and pharmacokinetics of…

Activity and heart rate monitor heart rate algorithm validation study

The primary objective of this study is to determine the equivalence accuracy of energy expenditure and resting heart rate measurement of newly developed software in reference to currently approved software. Secondary objective is to asses the…

Inclusive physiological assessment: impact of location of flow velocity assessment

Flow velocity measurements are more feasible proximal to a coronary stenosis than distal to a stenosis. The conservation of mass principle dictates that proximal flow velocity measurements can be used as a substitute for distal flow velocity…

Effects of ciprofibrate on myocardial insulin sensitivity in pre-diabetes

The main objective of the study is to investigate whether ciprofibrate treatment can improve myocardial insulin sensitivity in subjects with IGM. As secondary objectives we want to investigate whether ciprofibrate treatment also improves diastolic…

Rate Adaptive Atrial Pacing in Heart Failure Patients with Chronotropic Incompetence

Primary Objective The primary objective of this pilot study is to assess the ability of MV sensor driven rate adaptive atrial stimulation to restore the quality of life in CI heart failure patients.Secondary Objective(s)The secondary objectives of…

Multicenter post-market study to assess and im-prove patient response to CRT therapy with the amy-card 01C system(MAP-CRT)

We hypothesize that a noninvasive ECGI mapping-based system, like the Amycard 01C system, can provide information valuable for both selecting patients for CRT therapy, planning the CRT procedure, guiding the actual CRT lead placement during…