79 results
(1) To determine the frequency of antibody-mediated encephalopathy in children with seizure-related or (sub)acute onset neuropsychiatric disorders. (2) To identify the target auto-antigens of selected seizure-related and (sub)acute onset…
(1) To determine frequency of antibody-mediated encephalopathy in adults with new-onset epilepsy/status epilepticus or chronic epilepsy. (2) To assess outcome of antibody-mediated encephalopathy in adults with epilepsy, and identify markers for good…
Primary Objective: To gain more insight in the genetic susceptibility for AIH. For this we will study the presence of candidate genes in AIH patients, study genetic similarities with other auto-immune diseases and perform a whole genome association…
Primary Objective: 1. Determine if assessment of mucosal and serological immunological characteristics in combination with clinical indicators of disease behaviour and response to therapy can identify immune-based phenotypes with implications for…
De lnternational CIDP Outcome Study (ICOS) aims to describe in detail the variation in clinical and electrophysiological subtypes, current practice of treatment, clinical course and outcom in CIDP. The second objective is to define the clinical and…
This investigation aims to investigate connective tissue fibroblast activation in detail in the inflamed fibrotic connective tissue. By analyzing these cells in detail we hope to understand better how they are activated, so we can develop better and…
The primary aim of this project is to discover new cellular (non-invasive) biomarkers for the diagnosis and monitoring of immune-mediated liver diseases. Secondly we aim to effectively differentiate AIH from DILI and NAFL from NASH.
To investigate the pathophysiological link between RA and PD, and test the efficacy of RvE1 treatment in gingival tissue biopsies of RA-PD and RA risk-PD patients ex vivo.
To evaluate anti-inflammatory effects of statin therapy on vessel wall inflammation by means of FDG PET/CT in AS patients.
- To study the clinical characteristics and disease course of patients with LEMS with or without SCLC- To identify the characteristics of the humoral or cellular immune response that are associated with the prolonged survival of patients with SCLC…
Aim of this study is to obtain synovial tissue and synovial fluid, from 80 patients with non-septic, inflammatory knee arthritis undergoing routine arthroscopy of the knee and analyze inflammatory factors influencing osteoclast and osteoblast…
PRIMARY OBJECTIVE• To find early bio-markers within 3 months of the treatment with biopharmaceuticals (BP) able to predict immunization against BP within the first year of treatment.SECONDARY OBJECTIVES• To analyze the correlation between…
Primary objective: to study the effect of faecal transplantation in a phase II randomised placebo controlled design on simple clinical colitis activity index (SCCAI) and endoscopic Mayo score. Secondary objective: to study intra individual changes…
Primary Objective: To investigate the presence of periodontitis in ACPA and or RF positive patients with arthralgia*s.Secondary Objective: to unravel the role of the cellular immune response in ACPA positive persons with arthralgia*s who are at risk…
The prevalence of anti-CCP in periodontitis patients.
Primairy objective:* To assess whether a poor vitamin D status in RRMS patients is negatively associated with cognitive performance in neuropsychological tests (information processing speed and working memory) and with measures of cognitive (dys)…
To establish compare vessel wall dimensions and inflammation in AS with healthy matched control subjects with MRI and PET-FDG
The objectives of this initiative are:1. To establish the disease oriented biobank; processing and storage of blood and CSF specimens and health information of MS patients (which may include health records, family history, lifestyle and genetic…
To study the effect of different treatment modalities, in newly diagnosed ITP patients, on disease activity, platelet activity, the results of the MAIPA, and the relation between these.
1) The primary objective of this pilot study is to compare the clonal composition of the TCR repertoire in anterior fascicular sural nerve biopsies with the TCR repertoire in peripheral blood of CIDP patients with active disease in order to identify…