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Ultrasound-guided biopsy from hand joints in arthralgia or arthritis patients: a feasibility study

To determine the feasibility of performing US-guided synovitis and tenosynovitis in wrist and MCP-joints, and investigate the quality and quantity of the obtained tissues.

A TWINSS extension trial to evaluate the safety and tolerability of CFZ533 (iscalimab) at two dose levels administered subcutaneously in patients with Sjögren*s Syndrome

The primary objective of this study is to evaluate the safety and tolerability of iscalimab at two dose levels (600 mg and 300 mg) in patients withSjögren*s Syndrome, who participated in the TWINSS core study,CCFZ533B2201.Secondary…

Rac1/pSTAT3 expression: Towards a potential pharmacodynamic marker to optimize and individualize thiopurine therapy in IBD patients

The aim of this study is to explore intra-individual differences in expression of Rac1 and pSTAT3 in leucocytes of IBD patients before and during thiopurine treatment.

Clinical observational study on the relationship between digital and clinical parameters of fatigue and sleep in neurodegenerative disorders and immune-mediated inflammatory diseases

Identify and evaluate digital parameters of fatigue and sleep that reflect daily self-reported measures in a mixed disease patient population.

Pharmacokinetics of the CYP3A substrate Midazolam after steady-state dosing of IMU-935.

In this study, we will evaluate a possible interaction between IMU-935 and midazolam. We will do this by investigating the effect of IMU-935 on how quickly and to what extent midazolam is absorbed, transported, and eliminated from the body. In…

Vaccine response against SARS-CoV-2 in patients with primary Sjögren*s syndrome

The primary objective is to study protective antibody responses after SARS-CoV-2 vaccination in patients with pSS. Secondary objectives are monitoring of adverse events and disease activity after vaccination, studying the prognostic value of anti-…

Disease occurrence And Inflammation in relation to Raw cow*s milk consumption in elderlY people.

The main aim of the proposed study is to 1) assess the habitual consumption of raw cow*s milk among a large population of adult dairy farmers; 2) assess the association between raw cow*s milk consumption and inflammation-related, auto-immune and…

STOPPING OF DISEASE MODIFYING TREATMENTS AND OLIGOCLONAL BANDS IN PEOPLE WITH MULTIPLE SCLEROSIS

Primary Objective: • To compare the proportion of MS patients with OCBs between patients with and patients without recurrent disease 12 months after cessation of DMTs. Secondary Objectives: • To explore differences in CSF/ blood IgG indices between…

Phase I, Open-Label, 2-Period, Single-Sequence Study to Evaluate the Mass Balance and Absorption, Disposition, Metabolism and Excretion of [14C] enpatoran, and the Absolute Bioavailability of Enpatoran in Healthy Male Participants

The study includes 2 periods, Period 1 and Period 2. Subjects will participate in both periods. Period 1:The purpose of Period 1 is to investigate how quickly and to what extent enpatoran is absorbed, transported and eliminated from the body (this…

A Phase 2, Multicenter, Open-Label Extension (OLE) Study to Observe the Long-Term Efficacy, Safety, and Tolerability of Repeated Administration of Upadacitinib (ABT-494) in Subjects with Crohn's Disease

This study has been transitioned to CTIS with ID 2024-510727-19-00 check the CTIS register for the current data. The primary objective of this study is to observe the long-term efficacy, safety, and tolerability of repeated administration of…

Optimizing Ankle Imaging in Juvenile Idiopathic Arthritis

Our primary goal is to develop and validate a Juvenile Arthritis MRI Score (JAMRIS) for the ankle. Secondly, to evaluate the individual and interdependent value of optimized 3.0 Tesla magnetic resonance imaging (MRI) and ultrasound (US) for the…

REgistry of Sjögren syndrome in Umcg - LongiTudinal (RESULT)

Primary: To identify biomarkers and clinical parameters that determine and predict the longitudinal course of pSS, taking into account patient-reported, functional, imaging, histopathological, laboratory and genetic data. Secondary: A) To identify…

Walking fatigability and the relation to walking economy and walking quality and the impact on social role participation and daily life activity in persons with Multiple Sclerosis.

The main objective is to investigate the association between walking fatigability during the 6 minute walking test (6MWT) and walking economy in pwMS who are able to walk independently. Secondary objectives are to investigate the role of I. walking…

A Multicenter, Single Arm, Open-label Study to Investigate the Efficacy and Safety of
Ravagalimab (ABBV-323) in Subjects with Moderate to Severe Ulcerative Colitis Who Failed Prior Therapy

The main objective of Study M15-722 is to characterize the efficacy, safety, and tolerability of ravagalimab (ABBV-323) as induction treatment in subjects with moderately to severely active UC.

Intra-operative visualization and treatment of salivary glands affected by sjögren*s syndrome using contrast enhanced ultrasound sialendoscopy (ceuss): a pilot study

our aim is to investigate practical applicability and safety of contrast enhanced ultrasound sialendoscopy (CEUSS) in salivary Parotid and Submandibular glands affected by Sjögren*s Syndrome

A Phase 3, Double-Blind, Multicenter Study to Evaluate the Long-Term Safety and Efficacy of Baricitinib in Patients with Systemic Lupus Erythematosus (SLE)

PrimaryTo evaluate the long-term safety and tolerability of baricitinib in patients with SLE.

A phase 1, open label, 2-period, fixed sequence, study to assess the mass balance, absolute bioavailability of 14C-PF-06826647 in healthy male participants

The purpose of this study is to investigate how quickly and to what extent PF-06826647 is absorbed and eliminated from the body (pharmacokinetics). PF-06826647 will be labelled with Carbon-14 (14C) and can be traced in blood, urine, and feces.This…

A phase 1, open-label study to Investigate Drug-Drug Interaction (DDI) potential of
Nipocalimab with coadministration of Etanercept or Hydroxychloroquine in healthy participants.

The main purpose of this study is to investigate the effect of nipocalimab on how quickly and to what extent etanercept or hydroxychloroquine is absorbed, distributed, metabolized and eliminated from the body. The study consists of 2 parts, Part 1…

Pathogenic Antibodies and (Rapidly Progressive) Dementia syndromes

1) Establish a comprehensive clinical and antibody profile of autoimmune synaptic encephalitis in dementia syndromes. 2) To assess outcome and provide diagnostic guidelines who to test and in whom testing will be unnecessary, and elucidate…

Adoptive Transfer of T cell Receptor-engineered T cells to treat hepAtocellular Carcinoma recurrence after liver Transplantation: a preclinical feasibility study

To isolate and validate TCRs that exclusively recognize liver antigens presented by specific (*recipient*) HLA-molecules (LSARH) on the surface of tumor cells.