353 results
To study the efficacy, adverse events, logistic feasibility and costs of immunoadsorption for the removal of anti-GBM antibodies in patients with acute renal failure due to anti-GBM glomerulonephritis.
The Purpose of the study is to determine how quickly and to what extent two new formulations of UCB5857 (formulation A and B, administered by mouth) are absorbed and distributed into the body and how fast these are metabolized (broken down) and…
Our primary goal is to evaluate the individual and interdependent value of optimized 3.0T imaging and immunological biomarkers for the evaluation of disease activity in JIA, compared to clinical examination.
The purpose of the study is to investigate how quickly and to what extent GBR 830 is absorbed into, distributed in, and eliminated from the body (this is called pharmacokinetics). Furthermore, the pharmacokinetics of GBR 830 administered as…
To objectively investigate retinal function deterioration due to the inflammatory process by ERG. To investigate if risk factors for loss of ERG activity in uveitis herald more aggressive immunomodulation treatment to prevent visual loss.
The purpose of the study is to investigate how quickly and to what extent cenerimod is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics).
The primary study objective is to examine functionality and usability of a newly developed eHealth and serious gaming intervention, to ensure that the intervention is user-friendly and fits the needs of potential users. Based on these functionality…
In this single center cohort study the primary objective is to assess minimal residual autoimmunity (MRA) in RTX treated AAV patients. The primary objective is to routinely assess the composition of the memory B-cell and plasma cell compartment…
To determinate the efficacy and safety of golimumab in patients with ankylosing spondylitis in daily clinical practice prospectively. In addition, the effect of treatment with golimumab on the lipid profile will be monitored during this study.
The main objective of the study is to see if the test compounds can prevent the development of a psoriatic lesion induced in non-lesional skin from psoriasis patients which has been transplanted onto immune-deficient mice.
MOODSTRATIFICATION is a large, multi-center international study supported by the EU. Workpackage 3 aims to establish a proof-of-concept for a succesful therapy-stratification model for use in patients with a moderate to severe depressive episode.…
NAM, well known as a dietary supplement, has also been extensively studied in humans in a variety of diseases in both children and adults. However, the bioavailability of NAM in patients with JIA at the side of inflammation, and therefore it*s…
The aim of this study is to investigate the use of cobicistat to reduce the required dose and dose frequency of tofacitinib in the treatment of RA.
The main objective of this study is to characterize the pathogenic B cells and the auto-antibodies that are responsible for causing the myasthenic or pemphigus syndromes. The secondary objective is to generate recombinant antibodies based on the…
Rationale:The aim of this study is to investigate the pharmacodynamics (PD), pharmacokinetics (PK), safety, tolerability, immunogenicity, and clinical efficacy of efgartigimod coformulated with recombinant human hyaluronidase PH20 (rHuPH20)…
The main objective of this study is to assess effectiveness of the COVID-19 vaccinations, based on humoral (anti-coronavirus antibody) immunity, in GCA and PMR patients. Other objectives are assessing antigen-specific cellular (T-cell) immune…
To assess the PK/PD relationship of prednisolone regarding toxicity as clinical outcome in paediatric patients with autoimmune or autoinflammatory diseases.
The primary goal of this study is to determine discrepancies between INR measurements with Coaguchek XS and Coagulometer in APS patients. The secondary objective is to investigate which antiphospholipid antibodies correlate with the observed INR…
We aim to use the results from genome-wide association studies (GWASs) of phenotypic, disease-related data of individual MS patients to provide insights into genes contributing to disease severity and burden (primary objective), and effectiveness of…
Benepali® and Brenzys® are approved as drugs that are administered as a subcutaneous (under the skin) injection using a pre-filled syringe. With a pre-filled syringe the drug is delivered through a needle which is inserted manually into the skin.…