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Repeat CT scans for evaluation of inter- and intrafraction motion and it*s effect on radiotherapy dose distribution during curative radiotherapy for pelvic tumours; An exploratory pilot study.

To explore the extent of inter- and intrafraction anatomical changes of the tumour and surrounding normal tissues, throughout the full course of treatment, and to subsequently assess the impact of these changes on the nominal planned dose. This…

Topical treatment of perianal dermatitis with potato protease inhibitor cream in children after colorectal surgery.

To address the hypothesis that a potato derived protease inhibitor cream significantly limits perianal dermatitis in patients after colorectal surgery.

Colonic motility distal to a deviating ileostomy after rectal resection and construction of a primary anastomosis

The primary aim is to study colon motility following rectal resection with the construction of a deviating ileostomy in patients that received an enema as bowel preparation. We hypothesise that CTT is halted or decreased, similar as in patients that…

Prevention of septic complications in low anterior resection for rectal carcinoma: the role of Platelet Derived Growth Factors. A pilot study

To investigate the feasibility of using L-PRP on anastomosis to prevent septic complications from occuring.

COMpression anastomosis ring (CAR* 27/ColonRing*) Post maRketing Evaluation Study

A new surgical device for the creation of compression anastomoses, the ColonRing*, which is nickel- titanium based, has been introduced. Safety and efficacy of the device have been established in previous clinical studies and the device has been…

Perianal and anorectal complications in patients with inflammatory bowel disease in time

1.To prospectively evaluate the course of anorectal function in IBD patients with perianal lesions2.To establish potential biomarkers to predict the course of anorectal function in IBD patients with perianal lesions

Anorectal continence and defecation reflex tests: pilot study

1. To investigate whether we are able to initiate and measure the continence and defecation reflex in healthy human volunteers with our new method. 2. To compare the results of these measurements with those of existing techniques.3. To investigate…

Anorectal function and clinical symptoms in patients with a third degree anal sphincter rupture: longterm follow-up

- to establish the long-term alteration of anorectal function in women after promary repair of a third degree obstetrical anal sphincter rupture- to evalute the following complaints in women in late postpartum period after 3rd degree rupture:…

Prospective validation of a predictive model for pathologic complete response after chemoradiotherapy in rectal cancer:
A prognostic study

The long-term research objective is to be able to select rectum cancer patients who could receive a less invasive treatment. If prediction of response is possible, surgery may be avoided when complete response after chemoradiotherapy is expected or…

Prospective randomised multicenter study comparing the outcome of rubberband ligation and artery ligation of the hemorrhoidal arteries in the treatment of grade II and III hemorrhoids.

In daily practice there are many treatment modalities for hemorrhoids available. Since many years the rubberband ligation is widly used. Recently there are also positive results reported of the artery ligation procedure. This research aims to…

Simultaneous Integrated Boost Radiation Therapy with concomitant Capecitabine and Mitomycin-C chemotherapy for locally advanced Anal Carcinoma

Primary objective of the study is the assessment of the dose limiting toxicity (DLT) and the maximal tolerated dose (MTD) of capecitabine and mitomycin-C with concomitant SIBRT in patients with locally advanced anal carcinoma.Secondary objectives…

Non-randomised,open, multi-center trial evaluating feasibility and safety of Tachosil application on a colorectal anastomosis

The primary efficacy variable is if the TachoSil application was feasible. A feasible application implies that the entire TachoSil adhere, TachoSil covers at least 1 cm beyond the margins of the anastomosis line and if more TachoSil sponges are used…

Long-term follow-up in patients with congenital anatomical malformations.

Evaluation of long-term complaints and problems on medical, surgical, psychological, social-emotional, conditional and motoric area in patients with one or multiple congenital malformations. More knowledge on long-term morbidity will lead to better…

Feasibility study of Smooth Seton placement in patients with perianal fistulas

With this study we aim to determine the feasibility of Smooth Seton placement in patients with perianal fistulas

A Phase 2 Study of INCMGA00012 in Participants With Squamous Carcinoma of the Anal Canal Who Have Progressed Following Platinum-Based Chemotherapy

To assess efficacy of INCMGA00012 in terms of the ORR in participants with locally advanced or metastatic SCAC who have progressed after platinum-based chemotherapy.

CyTOF and microbiota analysis on Crohn*s disease-associated and idiopathic perianal fistulas

To determine the differences in immune cell populations, microbiota and fibroblasts between fistulas from patients with and without Crohn*s disease.

A Phase 3, Open-label, Long-term Safety Study of Oral Linaclotide Administered to Pediatric Participants with Functional Constipation (FC) or Irritable Bowel Syndrome with Constipation (IBS-C)

The objective of this study is to assess the long-term safety of linaclotide in pediatric participants with FC (total exposure with linaclotide for 24 weeks) or IBS-C (total exposure with linaclotide for 52 weeks) who have completed study…

An interventional, prospective IVD device study for the testing of DNA extracted from tumor tissue biopsy samples in a first line setting from patients diagnosed with metastatic Colorectal Cancer (mCRC) to determine the KRAS G12C mutation status as part of the inclusion criteria into the Amgen Phase III clinical trial (Protocol No 20210081) to demonstrate clinical performance of the therascreen® KRAS RGQ PCR Kit.

To utilize the therascreen KRAS RGQ PCR Kit, as a screening test in Amgen*s Phase 3 Clinical Study Protocol 20210081, in order to identify patients with mCRC KRAS G12C mutation positive tumors to be enrolled in the drug clinical trial. Results of…

Effectiveness and cost-effectiveness of rubber band ligation versus sutured mucopexy versus haemorrhoidectomy in patients with recurrent haemorrhoidal disease: a multicentre randomized controlled trial

The primary objective of this RCT is to compare the effectiveness of RBL, sutured mucopexy and haemorrhoidectomy regarding recurrence and patient-reported symptoms for recurrent grade 2 and 3 HD after at least 2 previous RBL treatments. Secondary…

Comparison of rubber band ligation and haemorrhoidectomy in
patients with symptomatic haemorrhoids, a multicentre,
randomized controlled trial and cost-utility analysis

This study investigates the two most commonly performed surgical procedures for treatment of grade III hemorrhoids. It aims to identify the best surgical treatment for this patient group considering quality of life.. Other outcomes measured are…