48 results
To explore the extent of inter- and intrafraction anatomical changes of the tumour and surrounding normal tissues, throughout the full course of treatment, and to subsequently assess the impact of these changes on the nominal planned dose. This…
Currently, there is no guideline for the treatment of perianal Crohn's fistulas. the aim of this study, in which surgical strategies (seton drainage and surgical closure with advancement plasty/LIFT) will be compared to medical treatment. We…
Objective: the use of autologous platelet rich plasma (PRP) as an adjunct to the staged mucosal advancement flap to achieve a better closure rate of high peri-anal fistula*s.
To address the hypothesis that a potato derived protease inhibitor cream significantly limits perianal dermatitis in patients after colorectal surgery.
The primary aim is to study colon motility following rectal resection with the construction of a deviating ileostomy in patients that received an enema as bowel preparation. We hypothesise that CTT is halted or decreased, similar as in patients that…
To investigate the feasibility of using L-PRP on anastomosis to prevent septic complications from occuring.
The purpose of this prospective randomised trial is 1) to compare short- and long-term efficacy of open selective haemorrhoidopexy with stapled haemorrhoidopexy; 2) to compare patients satisfaction between open and stapled haemorrhoidopexy.
Disease activity, perianal involvement and lesion localisation are important influential parameters making sure no pregnancy is exactly alike and mode of delivery needs to be considered on an individual patient level.A complete anorectal function…
Aim of the study is to get informed on the outcome of women treated in the MUMC for obstetric anal sphincter injury between 2005 and 2012. The controlgroup is matched for maternal age at delivery, parity, mode of delivery and child weigth.
To assess the potential benefit of pelvic floor therapy for anal fissure. Measured primarily in pain, measured by the VAS score. Secondary outcomes are healing rates and recurrence.
A new surgical device for the creation of compression anastomoses, the ColonRing*, which is nickel- titanium based, has been introduced. Safety and efficacy of the device have been established in previous clinical studies and the device has been…
Aim of the present study is to investigate whether LIFT or TAFR is the preferable treatment for high transsphincteric fistulas-in-ano of cryptoglandular origin.
1.To prospectively evaluate the course of anorectal function in IBD patients with perianal lesions2.To establish potential biomarkers to predict the course of anorectal function in IBD patients with perianal lesions
1. To investigate whether we are able to initiate and measure the continence and defecation reflex in healthy human volunteers with our new method. 2. To compare the results of these measurements with those of existing techniques.3. To investigate…
- to establish the long-term alteration of anorectal function in women after promary repair of a third degree obstetrical anal sphincter rupture- to evalute the following complaints in women in late postpartum period after 3rd degree rupture:…
The long-term research objective is to be able to select rectum cancer patients who could receive a less invasive treatment. If prediction of response is possible, surgery may be avoided when complete response after chemoradiotherapy is expected or…
In daily practice there are many treatment modalities for hemorrhoids available. Since many years the rubberband ligation is widly used. Recently there are also positive results reported of the artery ligation procedure. This research aims to…
To compare the Anal Fistula Plug with the fistulotomy in the treatment of low perianal fistula.
Primary objective of the study is the assessment of the dose limiting toxicity (DLT) and the maximal tolerated dose (MTD) of capecitabine and mitomycin-C with concomitant SIBRT in patients with locally advanced anal carcinoma.Secondary objectives…