17 results
Determine the existence of a relation between GER and apnea and their underlying mechanisms, in infants *37 weeks * 12 months.
To identify genetic risk factors associated with GERD.
Our hypothesis is that the brain processing of rectal sensation is impaired in children with functional fecal incontinence, leading to reduced cerebral activity during rectal distension. We will perform a pilot study using fMRI in combination with…
The first aim of this study is to identify factors which predict an improvement of gastroesophageal reflux after gastric banding. The second aim is to assess the effect of gastric banding on gastroesophageal reflux after the operation.
We aim to investigate the association between reflux episodes and supragastric belches using the technique of combined HRM and impedance monitoring.
The aim of the present study is to identify genes associated with functional constipation in a homogeneous subgroup of children responding to sacral neuromodulation by performing whole exome sequencing in both children and their parents and to…
Key objective: the hypothesis that will be tested Our hypothesis is that the decreased oesophageal acid sensitivity is mediated by oesophageal permeability changes. Furthermore we hypothesize that the electrical tissue impedance of oesophageal…
Key objective: the hypothesis that will be tested:Our hypothesis is that the proximal oesophagus of patients with GORD is more sensitive to acid than the distal oesophagus, which is due to more pronounced mucosal integrity changes in the proximal…
The first aim is to identify possible mechanisms which cause nocturnal reflux in obese subjects. Secondary aims are to identify the role of weight reduction on reflux parameters and to identify the relation between anthropometric parameters (BMI and…
The first aim is to determine the amount of nocturnal reflux (reflux time / 24 h) in obese subjects compared to normal weight subjects. Secondary objectives are to identify possible mechanisms which cause nocturnal reflux in this patient group and…
to study the relation between esophageal circular contractions and chest pain episode(s) in treated patients with achalasia by using 24-hour esophageal manometry combined with pH-metry/impedance
This study had two objectives:1. which factors determine outcome of treatment of children with functional childhood constipation referred to the outpatient clinic of multidisciplinary treatment clinics in the Netherlands;2. which factors can be…
Primary Objective: To evaluate whether exercise leads to an increase total reflux time. Secondary Objective(s): - To evaluate whether the increase in reflux correlates with: exercise intensity, failure of the LES to act as an effective barrier,…
The aim of this monocenter observational pilot study is to determine the incidence and severity of gastric emptying disorders in patients with a hiatal hernia and to observe the effects of hiatal hernia repair and fundoplication on the gastric…
Primary objective: Is het possible to induce fecal urge by pressure on the pelvic floor alone? Secondary objectives: - Is there a difference in the assessment of the rectal sensibility with an air- or a water inflatedballoon in left lateral position…
Primary objective of this study is to assess the responsiveness effect size of the ESM-PROM in examining changes in symptom scores between baseline and post-treatment. Secondary objectives are to identify differences in characteristics between…
To explore regions of brain and brainstem activation in healthy volunteers during abdominal pain or discomfort after chemical nociceptive stimulation of the duodenum with capsaicin. In the future, we aim to perform the same study in IBS-/FD-patients…