324 results
The primary objective of the present study is to evaluate the accuracy of platelet RNA profiling for occult cancer detection in patients of 40 years or older with a first episode of unprovoked VTE, in an investigator-initiated, multinational,…
Primary objectives- To investigate the safety and tolerability profile of hVEGF26-104/RFASE.- To determine the effective dose of hVEGF26-104/RFASE required to neutralize VEGF in serum, defined as a VEGF level below 9,0 pg/mL.Secondary objectives- To…
The aim of this study is to assess differences in tumour microenvironment between HPV+ and HPV- oropharyngeal HNSCC using [68Ga]Ga-RGD2 PET/CT and perfusion CT.
Primary: Phase 1: To estimate the RP2D and/or the MTD for PDR001.Phase II: To estimate the anti-tumor activity of PDR001.Secondary: Both phases: Safety and tolerability, PK profile, emergence of anti-PDR001 antibodies, other parameters for…
Primary objective: To evaluate the efficacy of MPDL3280A in patients with locally advanced or metastatic solid tumor whom, in the opinion of the investigator, based on available clinical data, may benefit from treatment with anti PD-L1 immunotherapy…
The main purpose is to establish the intraoperative use of cetuximab-IRDye800CW as a reliable marker for residual tumor in resection margins after surgical removal of HNSCC. The objective is to establish the positive predictive value of cetuximab-…
This drug-drug interaction (DDI) study is being conducted to determine if there is a pharmacokinetic (PK) interaction between trametinib and the components of combination oral contraceptives (OCs), norethindrone (NE) and ethinyl estradiol (EE).…
This study has been transitioned to CTIS with ID 2024-517381-42-00 check the CTIS register for the current data. This study aims to assess the safety of TEG001. Furthermore, the feasibility of TEG001 production with material from intensively pre-…
Primary objective: To evaluate pharmacokinetics (PK) of 89Zr-MPDL3280A in patients with locally advanced or metastatic solid tumor whom, in the opinion of the investigator, based on available clinical data, may benefit from treatment with anti PD-L1…
We aim to investigate in a pilot study the blood platelet mRNA profiles in patients with IIM and a known malignancy.
Primary objective:To assess the clinical activity of AL101 using radiographic assessments and RECIST v1.1 in ACC patients with activating Notchmutations.Secundary objectives:• To assess quality of life in ACC patients with activating mutations.• To…
Primary:* Phase I: to establish the recommended phase II dose (RP2D) of BCT-100 in children andyoung adults as assessed by dose limiting toxicity (DLT) and complete arginine depletion.* Phase II: to determine the activity of single agent BCT-100…
Primary objectives:* Part 1: To evaluate the safety and tolerability and determine the recommended dose(s) of INCB059872 for further study in advancedmalignancies.* Part 2: To further evaluate the safety and tolerability of INCB059872 for further…
Core:Core Primary Objective:* To investigate the safety and tolerability of OMO-1 when given orally to patients with locally advanced, unresectable or metastatic solid malignancies, alone or in combination with anti-cancer treatments, and define the…
Primary objective:To investigate whether MR-only radiotherapy in prostate and rectal cancer patients is at least non-inferior in terms of position verification performed by a registration between the pCT and CBCT instead of the CT.Secondary…
With this prospective study, we aim to investigate the relationship between skeletal muscle mass and cisplatin plasma pharmacokinetics in HNSCC patients treated with conventional primary and postoperative CRT with cisplatin. It is designed to be a…
Primary study objectives:· To determine the safety [(adverse event profile, dose-limiting toxicity (DLT) and maximum tolerated dose (MTD)] of JNJ-26483327in male and female subjects with cancer.· To determine the pharmacokinetics (PK) of JNJ-…
To assess the response rate to the combination of gemcitabin plus oxlaiplatin in 5 different strata of relapsed/refractory pediatric solid tumors, in whom standard treatment has failed. Secondary objectives are the safety, the duration of response,…
The MR-Linac Technical Feasibility Protocol For Development of MR-guided Adaptive Radiation Therapy.
Primary: To test the feasibility of multiple techniques / software for MR-guided adaptive radiation therapy on the Elekta Unity MRL.Secondary: To register acute grade >= 3 toxicity.
The main objective of the study is to assess efficacy of engineered IgA antibodies (anti-EGFR, anti-EpCAM) in inducing specific tumor cell killing by myeloid immune effector cells. The secondary objectives of the study will be:-To evaluate relative…