212 results
The primary objective of the study is to ascertain the feasibility and safety to image tumor angiogenesis in head- and neck cancer patients using Ga-68-DOTA-RGD2 PET/CT. Secondary objectives are to determine the pharmacokinetics and biodistribution…
The current study is a continuation of the cohort 5-8 years post-diagnosis and aims to evaluate:1.The course of the nutritional status, and the related factors and consequences of malnutrition in survivors of childhood cancer until 5-8 years post-…
The goal of this study is to be able to perform reliable measurements on AROM of neck and shoulders , exercise capacity, strength, MMO and functional mobility to evaluate the effectiveness rehabilitation programs in head and neck cancer survivors.
Primary objective* To determine safety and the maximum tolerated dose (MTD) of SAR405838 through the characterization of dose-limiting toxicities (DLTs).* To assess biological activities of SAR405838 in patients with dedifferentiated liposarcoma…
The main objective is to estimate the MTD(s) and/or RDE(s) of IDH305 in patients with IDH1R132 mutant malignancies, as measured by the incidence of dose-limiting toxicities.Secondary objectives are characterization of the safety, tolerability, PK…
Primary objectives:- To evaluate the toxicity and feasibility of a DLI-combined minor H ag UTA2-1 peptide-loaded, PD-L silenced donor DC vaccination in B cell hematological malignancies- To evaluate the effect of a DLI-combined minor H ag UTA2-1…
To compare the effects of exercise therapy on mouth opening using the TheraBite and the DTS in a randomized controlled trial in head and neck cancer patients suffering from trismus.
The main objective of this study is to develop a PDT and salvage surgery combination specific for recurrent or residual tumors of the sinonasal cavities, unsuitable for the conventional treatments like radical surgery or radiotherapy with curative…
The aim of this international field study is to test the scale structure, reliability, responsiveness to change and validity of the EORTC SHQ-C22 in patients with different cancer diagnoses, at different stages of disease, and with different…
The primary objective of the study is to determine the mean prediction error (MPE) and mean absolute prediction error (MAPE) of the area under the plasma concentration-time curve (AUC) of carboplatin after adjusted dosing for high BMI (BMI >…
Primary objective- To evaluate the uptake of 68Ga-PSMA in locally advanced, recurrent and metastatic ACC or SDC by performing 68Ga-PSMA-PET/CT scans.Secondary objectives- To calculate the SUV tumor-to-background ratio and tumor-to-*healthy salivary…
The primary objective of the study is to assess the anti-tumor activity for patients with GBM with a translocation or amplification in FGFR1,2,3 or 4 based on PFS.The secondary objectives of the study are to assess the anti-tumor activity for…
Primary objective: To determine the MTD/highest studied dose determined to be safe, the safety and tolerability of INC280 as a single agent when administered orally to adult patients with c-MET dependent advanced solid malignancies.Secondary…
Objectives:• To allow continued access to tivozanib for subjects who have participated in other tivozanib (monotherapy orcombination) protocols, who are tolerating study drug and displaying clinical benefit.• To assess long-term safety and…
To gain insight in mechanisms of case management and in succesful and less succesful aspects of case management in individual patient care. This leads to knowledge of potential added value of case management to regular care and (if there is added…
The primary objective of the study is to provide evidence that the use of a sealing surgical patch applied to the surgical field following parotidectomy is non-inferior in efficacy to the common practice of CSD insertion by wound closure, measured…
The primary objectives of our study are to evaluate safety, toxicity and capability of inducing T cell responses of vaccination with, monocyte-derived donor DC electroporated with mRNA encoding hematopoietic-restricted MiHA in patients who had…
Primary Objective: to study the influence of a BMI < 20 or a BMI > 25 on the clearance of fentanyl, in patients using a stable dose of the fentanyl patch (Durogesic ®).to study the effects of smoking on the clearance of fentanyl, in…
a. Generate a tissuebank of fresh frozen tissue samples for biomarker research by establishing protocols and logistics for tissue collection, storage, annotation and retrieval. With additional goal the applicability in the standard clinical…
Aim of this study is to investigate the tolerance and the outcome of extreme hypofractionated RT for prostate cancer by delivering a high dose using two alternative time schedules, a short and long treatment interval.