212 results
To determine if PHA-739358 has an antitumor activity against breast, ovaria, pancreatic, colerectal, small and non small cell squamous lung cancer.
- To asses the safety and toxicity of peri-ablative sorafenib given in doses of either 200 mg or 400 mg twice daily.- To asses the effect of perioperative sorafenib on the RFA induced mobilization of endothelial progenitor cells and cytokines…
The primary objective is to determine the safety and the maximum tolerated dose of dasatinib in combination with lenalidomide and low dose dexamethasone in subjects with relapsed or refractory multiple myeloma
Primary objectivesIn all patients included in the studyTo asses whether:- MP-TF activity and MP phenotype is associated with specific types of malignancy.- MP-TF activity and MP phenotype predicts for development of thrombosis.- MP-TF activity and…
The aim is to study if Neurofeedback can be an applicable intervention.for survivors of childhood brain tumours. The QEEG wil be investigated whether under or overactive brainareas exist which can be trained. This study will also investigate whether…
To evaluate the safety and tolerability of escalating doses of oral sunitinib in combination with standard doses of intravenous ifosfamide in patients with solid malignancies.
The sequential application of chemotherapy and radionuclide treatment in patients with symptomatic osseous metastasized prostate cancer. Patients with more than one painful osseous metastasis will be randomized between 153Sm-EDTMP or docetaxel 3…
To identify novel childhood cancer-predisposing genes in children.
To investigate the long-term safety, tolerability and acceptability of Nasalfent in the treatment BTCP
The aim of this study is to investigate the effect of incorporating a CT-thorax in the target volume delineation process on 1) percentage of the target volume that receives less than 85% of the prescribed dose, 2) the size of the irradiated boost…
Primary objective: To study the influence of repeated oral administration of ketoconazole, a potent CYP3A4 inhibitor, in a therapeutic dose on the plasma pharmacokinetics (PK) of eribulin administered via intravenous (IV) infusion.Secondary…
In the past there has been little attention for quality of life, of which sexuality is an important part, in both scientific research and in clinical practice. Nowadays things are changing and talking and thinking about the sexual functioning and…
Primary objectives: To compare the dose volume histograms (DVHs) of the planning target volume (PTV) in prone and supine position, with 3D conformal and intensity-modulated radiotherapy (IMRT) planning in patients who receive pelvic irradiation To…
Primary objective: To assess the potential effect on QTcF interval (QTc Fridericia) of cabazitaxel in cancer patientsSecondary objectives:• To assess the effects of cabazitaxel on heart rate (HR), QT, QTcB (Bazett*s correction), and QTcN (population…
To study the mechanism of cisplatin induced hypomagnesemia.To identify predisposing factors for cisplatin induced hypomagnesemia.
To study the underlying demographic, clinical and pharmacogenetic factors contributing to the failure of achieving analgesia and/or the occurrence of dose-limiting side effects in individual cancer patients for seperate opioids;- To study if the…
Identifying factors that are involved in the way social support is experienced by the patient when confronted with cancer.
To determine the feasibility of a trainingprogram in childhood cancer survivors in the primary health care system
Primary: To demonstrate the superior efficacy of Nasalfent in the treatment of BTCP in opioid tolerant subjects who are receiving regular opioid therapy.Secondary: To demonstrate the safety, tolerability, and acceptability of Nasalfent in the…
The primary objective of this study is to determine the excretion balance and to elucidate the metabolic pathway of eribulin in vivo after a single dose of carbon-14 radio-labeled eribulin (14C-eribulin), inpatients with advanced solid tumors.