212 results
Goal of the UMBRELLA Study is the optimization of existing MRI protocols and processing techniques required for MRI guided radiation treatment on the Marlin system (MRI of the MR-Linac) and diagnostic MRI scanners in the radiology department needed…
To add 36 benign control patients to the Expect study to investigate whether detection of a KRAS mutation by ddPCR in peritoneal fluid is truly specific for pancreatic cancer.
This study has been transitioned to CTIS with ID 2024-513843-10-00 check the CTIS register for the current data. Primary objective: Assess the short term safety and tolerability of 68Ga-SATO in pediatric patients with NBLSecondary objectives: -…
The aim of this proposal is to test this concept using organoid cultures and biobanked material of colon cancer patients and use these cultures to develop novel therapies in particular for the CMS4 subtype, which has mesenchymal features, a dismal…
In this pilot study, we want to investigate whether it is feasible to study the accumulation of changes in mtDNA in non-cancer cells as a possible explanation for the development of fatigue in patients treated with chemotherapy for metastatic…
Primary objective:To investigate in Adolescent and Young Adult (AYA) Head and Neck Cancer (HNC) survivors treated with unilateral radiotherapy 5-10 years before, the long-term vascular complications in terms of carotid wall changes (ultrasonography…
The objective of this study is to develop a method whereby reliably can be determined if there are microscopic metastases in the neck lymph nodes of H&N cancer patients. In those patients with "clean" nodes the irradiation can be…
Our main objective is to dissect the genomic determinants of treatment-related adverse events after lymphoma, specifically cardiovascular disease and second malignant neoplasms. As such, we will assess the association of genetic and epigenetic…
This study has been transitioned to CTIS with ID 2024-516922-70-00 check the CTIS register for the current data. Phase I• Primary objectives:o To study the safety and feasibility of AT with autologous MC2 TCR T cells, combined with epigenetic drug…
Objectives: The primary objectives of this study are: • Part 1 (dose-escalation): To evaluate the safety of SYD985 in combination with niraparib to determine the maximum tolerated dose (MTD) and recommended combination dose regimen for expansion (…
To gain insight into the incidence of retinopathy and optic neuropathy in relation to the radiation dose in order to develop a normal tissue complication probability (NTCP) model for the eye and the optic tract.
To investigate whether a tailored physical activity program that starts early (during curative chemotherapy with cardiovascular toxic potential) is superior in terms of reducing long-term cancer-treatment-related metabolic syndrome and…
To develop a dosing nomogram of irinotecan in patients homozygous polymorphic for UGT1A1*28 and/or UGT1A1*93 in order to reduce the incidence of severe irinotecan-associated toxicity, defined as febrile neutropenia during the first two cycle of…
This study has been transitioned to CTIS with ID 2024-512824-13-01 check the CTIS register for the current data. The overarching goal of this study is to improve adequate resection of oral cancer. We will perform a clinical trial to determine the…
Primary Objectives:Phase 1/ Dose escalation:• To determine the safety and tolerability of INT-1B3, administered as single agent by 120-min i.v. infusion• To identify the Recommended Phase 2 Dose (RP2D) of INT-1B3 Phase 1b/ Dose expansion:• To…
To assess the proportion of patients who are alive without disease progression at 6 months based on local investigator assessment per RECIST v1.1 in cohort A and cohort B 13-03-2019: new cohort added (3 cohorts now)
This study has been transitioned to CTIS with ID 2024-510778-26-00 check the CTIS register for the current data. Primary Objective:To evaluate the efficacy of LN-145 measured by objective response rate (ORR) usingResponse Evaluation Criteria in…
To explore the feasibility and opportunities for new imaging procedures, of relevance of Amsterdam UMC prioritized areas, that a ultra-high sensitivity total body PET-CT system can offer for improving diagnosis and dose reduction.The protocol…
Overall aimThe overall aim is to assess whether associations can be identified between the presence of oral/dental foci, the composition of the oral microbiome, the incidence and severity of OM, and the risk to develop FN in cancer patients treated…
To evaluate the performance of a *genotype first approach* (WES-based panel analysis) in diagnostics of genetic predisposition in children with cancer or neoplasms, compared to the current *phenotype first approach* (standard of care). In particular…