212 results
We aim to identify immunological parameters during (immune)therapy. We will study the effect of (immune)therapy on generic immune mediators and more specifically for NK cell, T effector and Treg cell functionality. Furthermore, we will explore DNX…
We want to investigate what happens to the immune cells during different types of radiotherapy (schedules). With this study, we want to take blood samples from patients during their standard radiotherapy for cancer and determine the effect on immune…
Our primary objective is to determine how often and to what extent potentially pre-malignant oral fields extend beyond their visible lesion. If those "underestimated" lesions have a greater chance to recur, narrow band imaging-guided…
The aim of the study is to investigate the clinical feasibility of irradiation without a mask for head and neck cancer patients. Optical surface scanning will be used and the set-up accuracy, intra-fractional motion, patient friendliness, and…
1. To demonstrate the added value of intraoperative pancreatoscopy in patients undergoing partial pancreatic resection for the treatment of Intraductal Papillary Mucinous Neoplasm (IPMN) as it pertains to detection of discontinuous (skip) lesions in…
The primary objective of this study is to identify biomarkers predictive for response to chemo-immunotherapy in patients with lungcancer with a known driver mutation.Secondary endpoints are overall survival; time to biological progression, defined…
The main objective of this study is to evaluate the image quality of a new cone-beam CT imaging system that will be used to acquire images of a wide selection of anatomical locations in patients receiving radiotherapy for cancer.
The primary objective is to develop and clinically validate a fast multi-parametric MRI acquisition technique, for non-invasive and comprehensive characterization of the tumor*s vascularization, *vascular signature mapping*, at 3 Tesla (3T) and 7…
This study has been transitioned to CTIS with ID 2023-509460-19-00 check the CTIS register for the current data. *In the phase Ib study: to assess the feasibility and safety of the addition of nivolumab and/or ipilimumab to MMC/capecitabine…
Primary objective* To study the antitumor activity and safety of crizotinib across predefined tumor types in patients whose tumors are harboring specific alterations in ALK and/or METSecondary objectives* To study the specificity of the kinase…
The primary objective is to perform a clinical validation of dried blood spot microsampling of imatinib, dasatinib, nilotinib, gilteritinib, midostaurin, and venetoclax. The secondary objective is to test the feasibility of home monitoring (…
To determine the safety and feasibility of primer shot fractionation for NSCLC.
Primary Objectives• To evaluate in vivo complement activation after first-time treatment with paclitaxel, liposomal doxorubicin (Caelyx) or other complement-reactogenic compounds• To evaluate ex vivo complement activation after incubation of predose…
To study the immune effects of novel radiotherapy schedules by longitudinal immune profiling. There will be a specific focus on actionable immune targets and their temporal patterns that can be tested in future immune-radiotherapy combination trials…
The aim of the study is to investigate the accuracy of initial positioning, stability during treatment (intrafraction motion), and the number of interventions (repositioning) for radiotherapy treatments of head and neck cancer patients, positioned…
The goal of this pilot study is to 1. Investigate the feasibility of the lymphatic mapping procedure in locally advanced cervical cancer 2. Study the agreement of the lymphatic map with the radiotherapy treatment plan. Are all lymph nodes at risk…
Primary Objective: To assess the sensitivity and specificity of rhPSMA-7.3 (18F) PET in detecting N1 disease on a patient level compared to the histopathology of pelvic lymphatic tissue removed during RP and PLND. At least one positive pelvic LN on…
The primary objective of this study is to obtain accurate data regarding physical activity and body weight loss over time in patients with cancer who are undergoing primary curative cancer treatment (chemotherapy or surgery) and relate this to…
This study has been transitioned to CTIS with ID 2024-513897-23-00 check the CTIS register for the current data. The main objective of this study is to evaluate the use of molecular fluorescence imaging using cetuximab-IRDye800CW in the detection of…
Primary: To evaluate the sensitivity and specificity of dynamic contrast enhanced (DCE-MRI) to identify patients who have increased risk of disease recurrence (local, nodal, systemic) after radio-chemotherapy of cervix cancer.Secondary: To apply…