212 results
The objective of this study is to compare two IRE protocols for the treatment of LAPC that are currently being used in clinical treatment, to allow for the determination (based on survival and co-morbidity) of the optimal treatment protocol for IRE…
This study has been transitioned to CTIS with ID 2024-515885-15-00 check the CTIS register for the current data. Main objectives:• To evaluate whole body distribution of 89Zr-Df-crefmirlimab in cancer patients prior to and during treatment with an…
This study has been transitioned to CTIS with ID 2024-514266-39-00 check the CTIS register for the current data. Phase 1 Primary Objective(s):-to evaluate the overall safety and tolerability of NVL-655-to determine the RP2D and, if applicable, the…
To assess the feasibility of participants positioned in an MRI scanner to regulate their breathing based on biofeedback
This study has been transitioned to CTIS with ID 2023-504491-15-00 check the CTIS register for the current data. • To evaluate the safety and tolerability of Runimotamab when administered as a single agent (Phase Ia) and in combination with…
This study has been transitioned to CTIS with ID 2024-519750-36-00 check the CTIS register for the current data. The primary aim of this study is to determine the feasibility of using intraoperative fluorescence-imaging (FLI) to identify laryngeal…
The objective of this study is to:1) explore the feasibility (recruitment, adherence, and absence of major technical problems) of using both medical-grade and consumer grade wearables for continuous measurement of physical activity, posture, balance…
Primary objectiveThe primary objective for this phase IIa study is to investigate the feasibility, usability and safety of CLS MR-guided FLA in the treatment of prostate cancer.Secondary objectiveTo assess tumor response and functional outcomes
To get a better understanding of the kinetics of the expression of CXCR1, CXCR2 and the CXCR1/2 ligands (including IL-8), blood samples of patients with breast cancer or sarcoma will be collected at different timepoints. We expect that with these…
We aim to establish the difference in immunological function of HNSCC patients undergoing (chemo)radiation with protons versus photons. These preliminary data are required to follow-up with larger studies to compare the effect of proton (chemo)radio…
This first-in-man study will investigate the safety and tolerability as well as establish a recommended dose of INCB081776 as a monotherapy (Part 1) and then in combination with INCMGA00012 (Part 2) in participants with advanced malignancies. During…
This study is performed to investigate the safety and feasibility of cryoablation during operation in adults in several brain tumors like gliomas, meningiomas, and brain metastasis. The primary objective is to assess safety in terms of complications…
The primary objective is to evaluate the safety, tolerability, and doselimiting toxicities, and determine the recommended dose for expansionof INCA00186 as monotherapy and of combination treatments of INCA00186 with retifanlimab and/or INCB106385 in…
The main objective of the study is to assess and compare the patient-reported swallowing function over the first year after randomization to either IMRT or TOS among patients with early stage OPSCC, SGSCC and HPSCC.
To assess the association between the presence of neutrophil subsets (CD16dim/CD62Lbright and CD16bright/CD62Ldim) and physical activity, physical fitness and complications in patients with esophageal or stomach cancer during curative treatment
Primary objectives:• To evaluate safety of repeat doses of [18F]AlF-RESCA-IL2.• To evaluate tumour uptake of [18F]AlF-RESCA-IL2 in patients with cancer.• To evaluate whole body distribution of [18F]AlF-RESCA-IL2 in cancer patients.Secondary…
To assess the safety and feasibility of performing a robot-assisted cervical esophagectomy (RACE) for patients with esophageal cancer.
The primary objective is to test the feasibility of daily adaptive radiotherapy plan based on the cone beam CT. The expectance is that this new technique will make the radiotherapy more precise which results in less side effects or patient could…
This study has been transitioned to CTIS with ID 2024-512822-28-00 check the CTIS register for the current data. The primary objective of this study is to evaluate the safety and tolerability and determine the MTD and RDE(s) of INCB123667 as…
This study has been transitioned to CTIS with ID 2023-504855-28-00 check the CTIS register for the current data. To determine the safety and tolerability and to establish a preliminary RP2D and/or an MTD or an MAD of MK-4464 administered via IV…