120 results
The main goal of this study is to assess whether CUDI-quantification of CEUS can successfully be correlated to malignant pathology results of kidney tissue.
To evaluate diagnostic accuracy of PSMA-PET/CT and FACBC-PET/CT in detection of lymph node metastases in initial staging of intermediate- to high-risk PCa.
The primary objectives of this study are to evaluate the safety and effectiveness of a novel diagnostic approach applying PSA-density and MRI-imaging-based monitoring, as opposed to immediate prostate biopsy, in men with an intermediate risk of…
To prospectively study the effect of salt restriction on the rise in blood pressure in response to anti-cancer treatment with the VEGF inhibitor sunitinib and regorafenib.
- Evaluate the safety and tolerability of up to 2 dosing cycles of GemRIS for up to 7 days per dosing cycle - Evaluate the pharmacokinetics of gemcitabine and 2',2'-difluorodeoxyuridine (dFdU, a gemcitabine-related metabolite) exposure in…
This study will evaluate usability, safety and performance of a cystoscopic guided injection of a marker (BioXmark) at the tumor site in patients with bladder cancer on planning CT and CBCT during the irradiation period.
To establish in vivo CLE characteristics of Upper Urinary Tract Urothelial Carcinoma
The primary objective of this study is to assess overall survival of patients who are diagnosed with incidental, histologically (biopsy) confirmed, <4 cm RCC and are managed conservatively with active surveillance. The secondary objectives…
1. To determine the frequency of mutations in known and novel pediatric renal cancer predisposing genes.2. To structurally document phenotypic characteristics of children with renal cancer, to optimize genetic counseling and surveillance and…
The aim of this study is to evaluate the dosimetry and toxicity of Lutetium-177-PSMA-617, in patients with low volume, hormone sensitive metastatic prostate cancer.
To directly correlate CLE images with histopathology, and identify and define CLE characteristics of normal urothelium, benign bladder urothelium, and bladder tumors (low-grade, high-grade NMIBC or CIS) of the lower urinary tract.
The objectives of this study are to:- Evaluate the safety and tolerability of up to 2 dosing cycles of GemRIS for up to 21 days per dosing cycle.- Evaluate the pharmacokinetics of gemcitabine and 2', 2'-difluorodeoxyuridine (dFdU, a…
To evaluate safety and feasibility of stereotactic body radiation therapy (SBRT) with fiducial markers in inoperable patients with renal cell carcinoma (RCC).The treatment is considered successful if all 5 treatments are completed and if in total…
- To study the success rate of organoid culture from lymph node, visceral and bone metastases in metastasized urogenital cancer and examine which parameters influence the success rate (culture media, biopsy site, cell counts). - To study the…
The primary objective of this study is to establish the success rate of culturing organoids from CTCs obtained by LA. Secondary objectives include to assess the fraction of metastatic PCa patients who have * 300 viable CTCs obtained by LA, the…
The primary objective is to explore if the presence of CD276-positive CECs in locally advanced or metastatic ccRCC patients treated with systemic therapy is worth more investigation. Furthermore, the clinical value of CD276-positive CECs will be…
This study has been transitioned to CTIS with ID 2022-502526-41-00 check the CTIS register for the current data. Objective- To evaluate anti-tumor activity of pembrolizumab (MK-3475) by evaluating the absence of high risk NMIBC or progressive…
Primary Objective:To evaluate the anti-tumor activity of pembrolizumab (MK-3475) (200 mg Q3W) as 1L therapy in subjects with advanced/unresectable (inoperable) or metastatic urothelial cancer who are ineligible for cisplatin-based therapy. Objective…
This combined phase I and II study is proposed to find the appropriate save dose level of one-fraction HDR-BT as monotherapy for low-risk PCa (phase I) and to evaluate the toxicity and clinical outcome of this dose level (phase II). In phase I,…
The primary objective:- To investigate the feasibility of capturing in-vivo cross section images of the bladder wall in bladder cancer patients with the OCT catheter.Secondary objectives:- To evaluate the duration of the OCT measurements. - To…