114 results
Primary objective:- To evaluate the pharmacokinetics, metabolism, and excretion of MDV3100 in plasma, urine, and feces after a single oral 160 mg (100 µCi) dose of 14C-MDV3100.Secondary objective:- To evaluate safety and tolerability of a single…
To identify pre-malignant lesions within the endometrium as precursor lesions of serous epithelial ovarian carcinoma.
The primary aim of this pilot study is to determine whether CTCs are a reliable predictor of survival in men with CRPC receiving docetaxel-based chemotherapy by using the Veridex CellSearch system and the biomarkers PCA3, TMPRSS2-ERG and biomarker…
To provide access to Radium-223 dichloride to patients diagnosed with CRPC/HRPC with bonemetastasis.
Our goals are to collect blood from men randomized to the intervention arm of the Dutch part of the European Randomised study of Screening for Prostate Cancer (ERSPC) and actually screened (www.erspc.org, N=19.970, METC 138.741/1994/152). With the…
Influence of Injection time of DCE-MRI for prostate cancer patients with consistent kinetic parameters.
Primary Objective:To compare the clinical benefit of abiraterone acetate plus prednisone versus placebo plus prednisone in patients with chemotherapy-naïve castration-resistant prostate cancer (CRPC) who are asymptomatic or mildly symptomatic.…
Confirm the interaction between colchicine and the choline pathway as seen with FCH-PET.
Primary:To investigate the safety and tolerability of ascending doses of AZD3514 in patients with metastatic castration resistant prostate cancerSecondary: To assess the pharmacokinetics and preliminary anti-tumour activity of ascending doses of…
Main objective of this study is to test the safety and feasibility of MR-guided focal cryosurgery in newly diagnosed prostate cancer patients and in patients with recurrent prostate cancer after radiotherapy. Secondary objectives are: to determine…
The goal of this project is to investigate the clinical feasibility of the robotic MRI-guided implant system for the implementation of fiducial gold markers for position verification for external beam radiation (or Intensity Modulated Radiotherapy (…
The objective of this study is to determine the efficacy of multiple intravenous infusions of MORAb-003 in platinum-sensitive subjects with a first relapse of epithelial ovarian cancer (including fallopian tube and primary peritoneal cancer) within…
The primary aim of the phase I part of this trial is to establish the safety of a split dose regimen of Re-188-HEDP . The primary aim of the phase II part of this trial is to obtain insight in the efficacy of a split dose regimen of Re-188-HEDP , as…
To test an intra-operative fluorescent camera system with a fluorescent optical agent in detection of the sentinel lymph node. This will be compared to the standard method with radiocolloid and patent blue.
to determine the feasibility of real-time detection and quantification of two NIRF optical contrast agents in the detection of sentinel and metastatic LNs in patients with cervical cancer during surgery with a novel NIRF imaging device to provide a…
The potential use of intraoperative, ICG based sentinel node identification, fluorescence imaging of LN*s during lymphadenectomy for prostate cancer
To obtain data, images and feedback from the initial clinical use of investigational four channel output eCoils designed for Siemens 1.5T and 3.0T scanners compared to the current, commercially available single channel eCoils for these field…
To compare sexual functioning and complaints concerning micturation and defecation in women after abdominal or vaginal trachelectomy for early stage cervical cancer.
To test a near-infrared fluorescence camerasystem in order to detect folate-FITC in tumour tissue in women with ovarian cancer who undergo cytoreductive surgery.
To study tumor oxygenation in woman with cervical carcinomaPrimarily: To study the feasibility of measuring tissue pO2 with the FDA approved Eppendorf needle electrode and to correlate these results with promising new non-invasive methods to measure…