18 results
PROVALID will have 3 major objectives:Primary: Determine the cumulative incidence of renal outcomes in patients with type II diabetes in different European countries. Renal outcomes are defined as:* Progression from normoalbuminuria to…
The characterization of T cells that reside in kidney transplants.The characterization of the T cell-mediated antiviral responses in kidneysThe role of kidney-resident T cells in acute and chronic allograft rejection
In this trial we will investigate the following hypothesis:- Uremic vasculopathy develops, not only in large and medium sized conduit vessels, but also in the microcirculation.- There is a relationship between the rate of microcirculatory…
the study aims to answer the following question:are components of innate immunity in general, and the complementsystem in particular, correlated with and usefull as predictors for the occurrence of macro- and/or microvascular complications in a high…
Our primary objective is to investigate if the previously found MSNA is related to the presence and severity of CV organ damage quantified as left ventricular mass, independent of other CV risk factors. We hypothesize that despite of treatment…
1. Demonstration of the relation between stage of CKD, CMV seropositivity and the presence of CD4+CD28- T cells2. Presence and cytotoxic potential of CD4+CD28- T cells in the peripheral blood of patients with endstage CKD and the relation with…
The main goal of the study is evaluation of the effects from renal artery stenosis on intrarenal flow-distribution and tubular function. Assumed and measured effects are alterations of medullary flow, inflammatory markers and overall tubular…
to develop standardized tubular function tests with reference intervals/values.
To establish the role of renal sympathetic modulation on renal blood flow, metabolism and oxygenation we propose three closely related series of experiments.Group 1: Sympathoactivation in healthy humans 12 healthy volunteers will undergo a graded…
The main goal of the current study is to confirm the origin of this sympathetic signal and compare it to the response in healthy humans. Secondly the goal is to assess the extent to which the suggested renal pressor response in CKD can be reversed.
to determine if there is an alternative mechanism for urine acidification in men in response to furosemide other than that through ENaC
1. To evaluate if podocytes directly cultured from the urine, and podocytes derived from induced pluripotent stem cells (iPSCs), can be used to prove causality of the VUS.2. Comparison of results obtained using iPSC-derived and urinary podocytes,…
Development of a predictive test for r-FSGS at the individual level of a patient and kidney donor with FSGS.
Objectives: 1. To what extent does the CVRM risk profile and co-morbid conditions differ between individuals with (UCC-SMART) and without (UHP-UCC) symptoms of heart failure, but with similar levels of echocardiographic structural- and functional…
To evaluate the prevalence of C-TMA in patients presenting with TMA, either with coexisting conditions or not. Furthermore, (i) the diagnostic performance of an in-house developed ex vivo test, (ii) dynamics of complement measures during follow-up,…
To analyze how potassium handling, volume and sodium status change in stable anuric chronic hemodialysis patients (CKD-5D) in response to higher dialysate potassium.
The aim of this pilot study is to further unravel the pathophysiologic mechanism of NS-induced hypercholesterolemia which willfurther guide the treatment of patients with NS.Given the recent insights on PCSK9-ENaC inhibition, our hypothesis is that…
Primary objective is to design a non-invasive, bedside monitoring strategy for early detection of renal graft hypoperfusion after pediatric kidney transplantation, using transabdominal ultrasonography and biomarker surveillance in serum and urine.…