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7 Tesla MRI protocol development

To further optimize 7.0 Tesla MRI techniques and to develop new MRI techniques that will enable state-of-the-art clinical and cognitive research leading to improved patient care. Whereas some applications of 7.0 Tesla MRI already show improvements…

Long-term follow up after implantation of Artisan Phakic Iris Claw Intraocular lens for the correction of high degree myopia

To evaluate the long term safety, efficacy, predictability, stability, complications and patient satisfaction after implantation of Artisan phakic intraocular lenses for the correction of high degree myopia.

Does oral administration of dabigatran etexilate, a direct thrombin inhibitor, achieve clinical significant concentrations of dabigatran and thrombin inhibiting activity in vitreous and subretinal fluid?

To investigate whether oral administration of dabigatran etexilate in patients with a rhegmatogenous retinal detachment leads to clinical significant dabigatran levels and thrombin inhibiting activity in the vitreous and subretinal fluid.

Assessment of corneal endothelial cell density: automated and manual measurements with specular photography compared to manual measurements with the confocal microscope.

To demonstrate equivalence for ECD between Topcon SP-1P Specular microscope and Nidek Confoscan 4.

The effect of Optic Neuritis, NAION and Pituitary Tumors on
the Attenuation Coefficient of the Retinal Nerve Fiber Layer
derived from Spectral Domain Optical Coherence Tomography images

To study AC changes of the RNFL in neuro-ophthalmic diseases.

Risk factors for glaucoma in musicians

Primary Objective:* To study the impact of playing wind instruments for the development of OHT and (progression of) glaucoma.Secondary Objective(s): * To study the risk factors for the development of OHT and glaucoma in professional musicians.* To…

Long-term results of IOL implantation in paediatric patients
A patient registry

To create a registry for paediatric patients with iris-fixated or posterior IOL*s, and the assessment of the long-term effects of implanted, artificial lenses in children.

Pilot study: Image-based, Diabetic macular Edema, Adjustment of Laser treatment - trial.

The aim of this proposal is twofold. Our first objective is to verify if indeed the OCT is more accurate in diagnosing CSME than SLB. Will more patients be diagnosed with CSME when examined with OCT compared to SLB? Our second objective is to…

Evaluation of the optic nerve head in healthy children with the Heidelberg Retina Tomograph.

Exact knowledge about the range of normal values is important for correct interpretation of HRT results in patients with a possible optic disc disorder. As a consequence, a number of studies have thus reported on normal values of healthy adults and…

Open-label Phase-4 study to examine the change of vision-related quality of life in subjects with diabetic macular edema (DME) during treatment with intravitreal injections of 2 mg aflibercept according to EU label for the first year of treatment.

Primary objectiveTo evaluate the change in quality of life (NEI VFQ 25) in subjects with DME during the first year of treatment with aflibercept according to the EU label for DMESecondary objectives• To assess further the safety and tolerability of…

SLO-imaging for quantifying the efficacy of Nd:YAG-laser vitreolysis for disturbing vitreous floaters.

To determine the efficacy of quantification of vitreous floaters captured by SLO-imaging technique for Nd:YAG vitreolysis for persisting vitreous floaters.

Clinical decision making in patients with cataract and Fuchs* endothelial dystrophy (FED): validation of in vivo confocal microscopy backscatter and OCT as a predictive measurements to decide to perform a phaco- or triple procedure.

To study IVCM backscatter measurements as a usefull measurement to decide between surgical indications.

Natural Peripheral Vision

Development of a method and diagnostic instrumentation for characterizing the peripheral ocular characteristics of normal subjects (with healthy eyes) in a clinical setting.Primary objective of the study: To measure the distribution of the ocular…

Functional recovery related to duration of macular detachment in retinal detachment after surgery

To demonstrate that functional outcome is correlated with DMD and ocular blood flow.

A pilot study towards a therapy with prednisolone encapsulated liposomes for the treatment of Graves* Orbitopathy with reduced systemic steroid exposure

To demonstrate that Nanocort is safe and effectively reduces the inflammatory signs and symptoms of active GO.

A Multicentre, Prospective, Longitudinal, Observational Natural History Study to Evaluate Disease Progression in Subjects with Usher Syndrome type 1B (USH1B)

To evaluate the natural progression of disease over time in USH1B patients using visual field testing and best corrected visual acuity.

Phase 3b Study for Management of Ocular Side Effects in Subjects with EGFR-Amplified Glioblastoma Receiving Depatuxizumab Mafodotin (ABT-414)

This exploratory study is designed to evaluate several depatuxizumab mafodotin-related OSE management strategies.The main objective of this trial is to estimate the percentage of subjects in each prophylactic treatment arm who require a change in…

Cataract surgery in eyes with an idiopathic macular epiretinal membrane: the effect on the epiretinal membrane and the surgical outcome

To quantify progression of macular ERM, and the degree of correlation with phaco-energy, after phacoemulsification.

EIS-GO: Early Identification of Steroid non-response in moderate severe active Graves* Orbitopathy,
a prospective study

To determine the accuracy of predicting steroid responders and non-responders with a whole blood in vitro steroid sensitivity assay.