76 results
The specific aim of the current study is to investigate the impact of oncological treatment and multiple GA in Rb survivors and Rb risk carriers (8-35 years) on cognitive functioning, psychosocial functioning and HRQoL. Furthermore, psychological…
Primary Objective: To evaluate persisting pulmonary morbidity and echocardiographic signs of pulmonary hypertension in young adults born with CDH that interfere with physical fitness and participation in society.Secondary Objective(s): To evaluate…
To report on the long-term effect modification by age of MPH treatment on brain structure and function, and clinical outcome, as measured by MRI scans, neuropsychological assessment, actigraphy and questionnaires, and to compare these results with…
Primary objective: To test in patients with ESRD whether a longer HD session (8 hours) compared with CHD limits the decline in cerebral blood flow.Secondary objectives: 1) to investigate whether a longer dialysis session is associated with superior…
Primary objective is assessment of the pharmacokinetic profile of MPD in pregnancy. Secondary objectives are the safety and efficacy of any use of MPD during pregnancy.
Goal of the study is to find out if cognitive remediation focused on executive functioning for patients with bipolar disorder improves (1) functioning on personal goals in everyday life? And (2) improves general wellbeing?Hypotheses:Cognitive…
Primary objective of the study: 1. To report on the long-term effect modification by age of MPH treatment on the outgrowth of the DA system using state-of-the-art Magnetic Resonance Imaging (MRI) techniquesSecondary objectives:1. To report on the…
In this study, we aim to validate the TICS and MoCA questionnaires against NPT, hoping to find a patient friendly and easy to use screening aid for preoperative evaluation clinics. Thus, aiding shared decision making regarding the appropriate…
We will study the cerebral glucose metabolism before, during and after surgery by sampling the cerebrospinal fluid (CSF) via the spinal catheter in patients undergoing thoracic surgery. Changes in cerebral glucose metabolism and activation of the…
1. Inventory of the current care of boys/men with Duchenne Muscular Dystrophy in the Netherlands: To establish the extent of implementation of the international guidelines and its updates in the Netherlands and to explore the relationship between…
To investigate the role of the dopaminergic system in reward discounting and reward anticipation in ADHD and comorbid disorders. The study investigates the following question: Do patients with ADHD without comorbidity differ from those with ADHD and…
To conduct a pilot study on the relationship between measured sensitivity to reward and the effectiveness of a routine cognitive-behavioral intervention in ADHD. To pilot relevant measurements and generate hypotheses for a larger study in the future…
The present study will investigate the association between Blood-Brain Barrier leakage and cognitive aging.Primary research question:1. a. Is stronger BBB leakage associated with greater decline in episodic memory?b. Post-hoc explorative analyses…
The objective is to research the psychometric properties (feasability, reliability and validity) of the Zuidwester Balans Schaal.
The purpose of the study is to investigate how quickly and to what extent balovaptan is absorbed and eliminated from the body when it is administered to healthy volunteers. The pharmacokinetics of balovaptan given by mouth (oral) will be compared…
The primary objective is to investigate in overweight or obese older adults the effect of daily protein supplementation for two weeks with either a plant-derived protein or an animal-derived protein on vascular function and insulin-sensitivity in…