16 results
To investigate whether peak melatonin level and daily secretion patterns differ between delirious and non-delirious older persons admitted to the ICU. To determine factors that potentially influence the association between delirium and melatonin…
To assess the potential of a short neuropsychological test measuring attentional variability and vigilance preoperatively in predicting postoperative delirium among elderly non-dementia patients undergoing elective surgery.
The primary outcome of this study is to assess whether the maximum ICDSC score achieved each day is related to PK parameters of haloperidol in ICU patients with delirium. Secondary outcomes: - To characterize the association between daily…
To investigate whether the Actiwatch® actigraph and the Everon* sensor can be helpful in the early diagnosis of a delirium. If both are able to do so, we evaluate which of the two performs best as a delirium screening device.
Objective: In this pilot study experience will be obtained in the simultaneous use of PSG, melatonin assay, CBT-measurement and assessment in ICU patients.
To examine how sensitive certain (combinations of) EEG parameters are for diagnosing delirium in a heterogeneous group of ICU patients during 24 hours of EEG registration. The delirium assessment by delirium experts will determine which patients…
The primary objective of this study is to test both the CAM-ICU and the ICSDS, using the DSM-IV criteria for delirium as golden standard. A secundary objective is to assess the value of the impression of the ICU physican whether or not a patient is…
Our objective is to validate multiple diagnostic instruments, especially the pCAM-ICU. By comparing these instruments, we can develope an algoritm which can be used by nursing staff to diagnose the pediatric delirium as soon as possible so that…
Primary objective:Plasma levels of clonidine, in order to describe pharmacokinetic and pharmacodynamic properties of intravenous clonidine in critically ill ventilated ICU patients.Secondary objectives are: * to evaluate the effect of a 3-hr loading…
The research question fort his study is: *What are the personal experiences of older hospital patients who have suffered a delirium, their family members, and their handling nurses?*. The aim of the current study is to gather the personal…
To obtain a nonlinear mixed effects model (NONMEM) describing the population pharmacokinetics of haloperidol in the central (CSF) and peripheral compartment after oral and intravenous injection.
Primary Objective: Testing the efficacy of tDCS as a 7 day add-on prevention in patients electively admitted to the ICU after cardiothoracic surgery on top of usual clinical care by measuring the change in delirium symptoms.Secondary Objective(s):…
Primary Objective: the relation between the occurrence of CSA-AKI and the duration of peri-operative low mitoPO2 measurements (<20 mmHg). Secondary Objective:- To study the relationship between the occurrence of postoperative cognitive…
1. The predictive value of the BAMCOG for developing postoperative delirium/postoperative acute encephalopathy in patients who underwent AVR surgery2. Concurrent validation of the BAMCOG with the MoCA3. The relation between cortisol levels in blood…
The primary objective is to explore whether sleep monitoring data correlate with DOS score in patients admitted for hip fracture.
Detection of delirium superimposed on pre-existing cognitive impairment or clinically manifest dementia (DSCID) is extremely challenging. As a direct consequence of these diagnostic difficulties patients tend to be misdiagnosed and thus mistreated.…