66 results
The main objective of this project is to study the relationship between dopaminergic mechanisms and apathy in dementia. The related question, both theoretically and of direct relevance for daily practice, is whether patients with dementia are…
The objective of this research project is to extend the knowledge of the prevalence of pain in patients who are admitted to a psychogeriatric wards of two nursing-homes.The key question is: what's the prevalence of pain in a group of nursing-…
The challenging aim of this three-year STREP project is to breakthrough with research that addresses the needs of those with dementia, particularly those with mild dementia in Europe. At about 2% of the elderly population, this comes to around 1,900…
The goal of this study is to examine the relation between a standardized observation scale by nurses with the formal results of neuropsychological tests by a neuropsychologist.
Validating a newly developed non-verbal testcase on the distinguishing ability to determine dementia. Validation by comparison through the "seven minute screen".
investigate who is at risk and to discover possible contributing factors of the development of paratonia in different dementing illnesses
Objective: to provide an answer to the following question: in patients with AD, does treatment with a ChEI improve cerebral autoregulation?
The objective of this study is to develop an evidence-based individualized intervention and to compare the effectiveness of this individualized approach with care as usual to reduce or prevent the increase of agitation (frequency or caregiver…
The objective of the current study proposal is therefore to investigate *the origin of cerebral small vessel disease*
Determine the reliability, validity and the sensitivity to change of the MYOTON Handheld Digital Palpation Device for measuring the severity of paratonia in patients with dementia and paratonia .Research questions are:(1) What is the validity of the…
The primary objectives are to study how exercise (i.e. actively performing exercise) affects frontal cortical activation (neurovascular coupling) and the effects on immediate cognitive performance of short periods of reduced and enhanced cerebral…
The study aims to improve the existing screening procedure for car drivers with dementia. It validates the current testing procedure and the decision procedure regarding fitness to drive. This is supposed to be beneficial to the safety of the driver…
This study has been transitioned to CTIS with ID 2024-517636-22-00 check the CTIS register for the current data. The main objective of the present study is to investigate the association between in vivo regional synaptic loss ([18F]SynVesT-1 PET),…
The objective of this study is to relate different vascular phenotypes, based on macro- and microvascular measurements, to changes in cognitive and physical functioning in a geriatric population.
Primary ObjectivePart1: To evaluate the safety and tolerability of intravenous (IV) administration of AL001 over up to 96 weeks in asymptomatic and symptomatic carriersof a granulin (GRN) mutation causative of frontotemporal dementia (FTD) and in…
The main objective of this study is to evaluate the feasibility of the Viamigo intervention among people with dementia living in the community and their informal caregivers. The secondary objective of this study is to assess the first responses of…
Primary objective:To explore the natural time course of specific [18F]AV-1451 binding in patients with subjective cognitive decline after two and four year follow upa. To compare rate of change in [18F]AV-1451 binding according to baseline amyloid…
The objective of this study is, to detect potential uses of plasma biomarkers in primary care, by (a) To investigate if plasma biomarkers are associated with working diagnosis in primary care.(b) To ascertain if diagnosis and patient management…
To investigate the trajectories of cognitive and adaptive functioning in adults with epilepsy and ID. In doing so we are looking for clinical determinants of cognitive and adaptive decline. Furthermore, the association between decline and serum…