36 results
The primary objective of this study is to predict the antidepressant treatment outcome of ECT in patients with severe depressive symptomatology using neuroimaging. ECT itself is conducted as usual according to national guidelines (Nederlandse…
The present study will evaluate potential etiological models for sleep disturbances, depressive symptoms and cognitive impairment using an innovative idiographic design using time-series analysis that accounts for both intra-individual variability (…
Identification of genetic variations that control monoamine and amino acid metabolism in humans, by translating recent genetic findings in non-human primates to a human cohort.
The objective of this pilot study is to investigate the association between hemodialysis-associated changes in tryptophan levels and changes in symptoms of depression and fatigue, and the temporal dynamics between depression and fatigue.
Primary Objective: 1. An explorative study to investigate whether a change in pain complaints or depressive symptoms can be predicted using baseline EEG/ERP measures derived from vulnerability experiments.Secondary Objective(s):1. To explore changes…
The aim of this study is to investigate the temporal dynamics between depressive symptoms and physical activity in post-MI patients, in order to prevent the deleterious effects of depression on heart disease prognosis and improve patient counselling…
The objective of this study is to investigate:1) the prevalence of insomnia in patients with T2D with and without depression2) whether insomnia in patients with T2D with and without depression, is associated with increased levens of HbA1C3) whether…
Primary Objective:1. To investigate, within individuals, the temporal dynamics of physical activity and depressed mood.Secondary Objectives: 2. To test mechanisms in and modifiers of the relationship between physical activity and depressed mood…
We will test a new theoretical model that assumes that mental health status interacts with the genetic factors influencing sympathovagal balance and the pro-inflammatory state. The results will be published in scientific magazines, and/or presented…
1. To determine demographic, clinical, and brain morphological and functional predictors for IST, and; 2. To examine their associations with the level of increase of seizure threshold (*ST) during the ECT course, as measured at every sixth ECT-…
The general objective of HELIUS is to describe (trends in) patterns of chronic conditions across six ethnic groups over time, and to unravel the causes of (the unequal burden) of chronic diseases across ethnic groups, with an emphasis on…
An observational study to test whether ECT induces epigenetic alterations of certain genes in blood lymphocytes and whether these alterations are associated with the cognitive side-effects of ECT treatment and the response to the treatment.
There are 3 objectives:1. What are the effects of intervention on depression outcomes on the long term?2. What is the long term course of depression in primary care for patients in the control conditions?3. What are the effects of attachment on the…
The aim of this research is explaining the difference between worrying and rumination in adolescents. The following research question is investigated: On which dimensions can rumination and worrying be distinguished?For answering this question, a…
A proof-of-principle study to test whether an environmental factor, i.e. here IFNα treatment, induces epigenetic alterations of certain genes in blood lymphocytes and whether these alterations correlate with the severity of psychiatric symptoms, i.e…
In this study we aim to investigate the possibility that part of the inconsistency regarding the relationship between neuroticism and the 5-HTT polymorphism is based on the moderating effect of early life trauma. A second reason for the…
1. To investigate neuropsychological deficits during an ECT course in relationship to cortisol levels 2. To investigate the underlying neural correlates, i.e. functional connectivity, structural connectivity, and amygdala reactivity, that are…
The aim of this study is to investigate the role of the HPA-axis in MAS-disorders. By measuring cortisol in saliva the HPA-axis functioning can be determined (endophenotype), and by collecting buccal cells from which DNA will be isolated, single…
The primary objectives :Are children of mothers with sub-optimal thyroid function and/or sub-clinical hypothyroidism and/or hypothyroxinemia during early pregnancy at risk for developmental delay at the age of two and does this possible delay…
Actualize, replicate and extend the data of NEMESIS-1 with regard to the prevalence, incidence, course and consequences (functioning, mental health care use and costs) of psychiatric disorders among the general population of the Netherlands.…