132 results
The primary objective of the present pilot study is: 1. To evaluate the temporal dynamics between neurofeedback parameters and depressive symptoms in older persons suffering from clinically relevant depressive symptoms. The secondary objectives are:…
Actualize, replicate and extend the data of NEMESIS-1 with regard to the prevalence, incidence, course and consequences (functioning, mental health care use and costs) of psychiatric disorders among the general population of the Netherlands.…
MOODSTRATIFICATION is a large, multi-center international study supported by the EU. Workpackage 3 aims to establish a proof-of-concept for a succesful therapy-stratification model for use in patients with a moderate to severe depressive episode.…
We investigate: (1) whether young women can be grouped according to distinct trajectories of depressive symptom change, measured with the Major Depression Inventory (MDI), over a period of 8 months following the breakup of a romantic relationship; (…
The primary aim of the current research is to gain insight into the background, and the precipitating factors of the suicides among adolescents aged, 10 to 20 years old, in 2017 in the Netherlands, by focusing on five domains and the last period…
Primary Objective: The primary objective is to establish the differential and sequential effectiveness of cognitive restructuring (CR) and behavioral activation (BA) (and the optimal sequence of these elements) on depressive symptoms (PHQ-2 at post…
Although electroconvulsive therapy (ECT) is an effective treatment for depression, preventing relapse after successful ECT remains a major challenge. In the PRASED-study we evaluate the effectiveness of three strategies to reduce relapse: an…
This study has been transitioned to CTIS with ID 2024-518101-18-02 check the CTIS register for the current data. The main objective of this project is to associate the gut microbial community with treatment efficacy (i.e., relieve in symptoms and…
the primary aim of this research is to investigate whether the development of ICD in PD after commencing dopamine replacement therapy can be predicted with baseline DaT availability. We also want to look at the (temporal) relation between the…
Primary objectives* To determine if 3-month PMTERGO decreases depressive symptoms in subjects with MDD* To determine if 3-month PMTERGO alters in vivo striatal DRD2/3 BP compared to pre-intervention levels in subjects with MDDSecondary objectives:*…
Primary objective: To investigate changes in biological and psychological markers for patients with an unipolar depressive disorder during treatment.. In specific, we will study the relationship between depressive symptomatology with changes in…
Evaluation of the feasibility of a trial on the efficacy of oral esketamine for the treatment of depression and/or demoralization in patients with advanced cancer who receive palliative care.
The project aims to improve mental health and wellbeing in the workplace by developing, implementing and evaluating an intervention targeting both clinical (depressive, anxiety disorders) and non-clinical (stress, burnout, depressive symptoms)…
The purpose of this study is to investigate how quickly and to what extent BI 1358894 is absorbed and eliminated from the body (this is called pharmacokinetics) when given as a single dose / multiple doses. BI 1348894 will be labelled with Carbon-14…
The main objective of the Brabant Study (BS) is to investigate possible different trajectories of thyroid function during pregnancy taking hCG hormone into account. Moreover, we aim to investigate whether pregnancy complications (e.g. pre-eclampsia…
The objectives of the current study, are to assess in a sample of remitted recurrently depressed patients over a 20-year follow up period: the long-term effects of PCT; the long-term predictive value of cognitive functioning on relapse and daily…
In this study we will investigate how safe the new compound seltorexant is and how well it is tolerated when it is used by healthy participants.We also investigate how quickly and to what extent seltorexant is absorbed, transported, and eliminated…
Preliminary guidance on how to support these patients in clinical practice will be derived. Primary objective is the change in drug concentrations in plasma (therapeutic drug monitoring) (mg/L) of the psychotropic drug after bariatric surgery (at 1…
The primary objective is to explore phenotypes of (sub)clinical PMDD and explore the impact of (sub)clinical PMDD on the lives of the affected women.The secondary objective is to assess the validity of a Dutch translation of the self-administered C-…
The overall aim of this explorative proof-of-concept study is to provide first evidence that treatment with VR-Moodboost will lead to symptom improvement in patients with depression. Primary objective:We hypothesize that VR-Moodboost will lead to an…