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The impact of short-term bed-rest on skeletal muscle mass and insulin sensitivity in healthy, young men

To investigate the impact of 7 days of bed-rest on skeletal muscle mass, strength and whole-body insulin sensitivity in healthy, young men.

Predictors for succesfull treatment of obesity

To identify predictors for the different treatment options for obesity (1. combined lifestyl intervention plus, 2. E-health treatment, 3. bariatric surgery; inclusion for treatment options 1 and 2 takes place in the EMC, inclusion for the treatment…

Human Brown Adipose tissue perfusion dynamics. The use of functional MRI.

To study the application of fMRI for the detection of BAT perfusion.

Energy expenditure and sleep in response to protein/carbohydrate and fat ratio

To determine energy expenditure and sleep in response to protein/carbohydrate and fat ratio of the diet over a short-term and long-term period of time.

Adaptive Thermogenesis and Obesity - The role of the sympathetic nervous system

To anwer the question: Is the elevation of energy expenditure and mitochondrial uncoupling smaller in obese than in lean subjects after mild cold exposure and what is the role of the sympathetic nervous system?

PGE2 levels, autophagy flux and mitochondrial function in ICU patients on enteral nutrition.

Studies of ex vivo muscle cell autophagy flux, leucocyte mitochondrial function and oxylipins, specifically prostaglandin E2 (PGE2) in critically ill patients during admission to an intensive care unit (ICU).

Medical assessment of adverse health outcomes in Dutch childhood cancer survivors; a nationwide project; SKION LATER Q2008 - Metabolic syndrome parameters in adult survivors of childhood cancer

• To study denominators of the metabolic syndrome in all survivors of childhood cancer• To compare the occurrence with previous disease and treatment components to identify subgroups at risk Metabolic syndrome• To study the overall frequency of the…