204 results
The overall objective of this study is to develop patient friendly and unobtrusive techniques to characterize motor function. In this context we will use video cameras combined with depth sensors (RGB-D sensors, such as Microsoft KinectTM) and…
Primary Objective: The primary objective of this study is to evaluate safety and tolerability of pridopidine in patients with HD.Secondary Objectives: The secondary objectives of the study are to assess the effects of long-term, open-label dosing…
Primary Objective: • To investigate the difference in localization of the lesioned area in the brain towards the preoperative assessed target and relate this to registration and rating of clinical tremor.• To investigate the role of the dentato-…
The purpose of the study is to investigate how quickly and to what extent UCB0599 and UCB2713 are absorbed, distributed, metabolized (broken down) and excreted from the body (this is called pharmacokinetics). Since UCB0599 and UCB2713 will be…
Our primary objective is to identify the disturbances in prosody, phonation and articulation with which dysarthria can be automatically recognized in speakers of Dutch, and German. To this end, we will first perform an experiment that involves the…
To assess whether forward extension of both arms improves gait initiation in patients with PD, measured by faster coverage of the initial two meters of walking. Secondary objectives are to determine whether this change in performance can be measured…
Objective: The primary objective of this study is to investigate whether pain experience decreases or increases when cognitive functions decline in patients with Parkinson's disease. Furthermore will be investigated whether this is influenced…
The main purpose of this research is to assess the interrater reliability (3 raters) of an instrumented clinical spasticity measurement. Also, the agreement will be determined between the instrumented and non-instrumented spasticity measurement.…
To evaluate the safety of E2007 given as adjunctive, long-term treatment in patients with refractory partial onset seizures with or without secondary generalization that completed the E2007-A001-206 or the E2007-G000-208 studies (revised per…
Primary Objective is to determine whether (A) patients with dystonia(plus) syndromes exhibit more psychiatric symptoms compared to a healthy control group and (B) whether dystonia patients show an altered serotonin metabolism (serotonin transporter…
Search for a relation between the concentration of haloperidol in serum and in liquor in elderly who reached a steady state of haloperidol. Secundairy aim: Cal inter-individual variation in serum and CSF concentrations, at the same dose haloperidol…
Aims:a) Understand persistence and/or plasticity of the brain correlatesb) Understand specificity of the brain correlatesQuestions:a) Which neural correlates of OCD are state dependent and thus normalized after successful treatment?b) Which neural…
Main Objective: - to validate the identified cognitive profiles prospectively in a new population using confirmatory cluster analysisSecondary Objectives: - to identify the clinical and demographical factors associated to the identified cognitive…
To explore the complex interaction between environment, autoimmunity and genetics in relation to the onset and clinical course of tic disorders and associated obsessive-compulsive symptoms and to translate these findings into clinical applications.…
The primary objective of this pilot study is to determine the effectiveness of four treatment options for local skin reactions induced by continuous subcutaneous apomorphine infusion, as compared to no treatment.The primary endpoint is the measured…
This research project exists out of two research questions:Firstly we will determine which gait parameters are associated with fall risk. Secondly develop a novel fall prevention program based on the associated fall risk gait parameters. To…
The primary objective of this study is to determine if and how specific characteristics of visual information influence the motor control strategy adopted by healthy subjects during a visuomotor tracking task. Changes in wrist joint impedance (i.e…
The main objective of this study is to evaluate whether the PowerGlove is a valid instrument that can be used for the assessment of hand motor symptoms in patients with Parkinson*s disease. Sensitivity, specificity, intra-examiner reliability and…
The aim of the study is to investigate the differences in multi-joint coordination between healthy young and healthy elderly. Secondly, we want to study adaptation of ankle and hip strategy with the application of whole-body force fields and…
Objective:The aim of this project is to apply motor-cognitive-mental elements together for psychiatric diagnosis, treatment, and prevention. We will examine and quantify the diagnostic value of motor-cognitive-mental elements in predicting (a)…