204 results
Primary Objective: Determining the prevalence in advanced-stage PD patients of increased bacterial TDC activity in faeces and the prevalence of increased AADC activity in serum.Secondary Objectives:- Correlating TDC activity and AADC activity to…
Primary aim:Our primary aim is to repeat our previous pilot study (REMPET2) in a larger cohort of patients; i.e. to measure PDRP expression in approximately 159 iRBD patients at two-time points, with an approximate interval of four years. This data…
The primary objective of this study is to compare cholinergic innervation of the cerebral cortex of GBA-PD and non-GBA-PD patients, using [18]FEOBV PET imaging of the brain.
The primary objective of this study is to establish a cut-off score on the MoCA, with a high, preferably 100%, sensitivity and reasonable specificity (>70%), in order to identify patients who will fail the CBR assessment, being unfit to drive…
To assess the local and systemic safety and tolerability of continued ABBV-951 treatment delivered as a CSCI for 24 hours daily.
Primary objectives: 1. Assess the feasibility of FMT in PD patients.2. Assess the safety of FMT in PD patients. Secondary objectives:1. Explore whether FMT leads to alterations in motor complications (fluctuations or dyskinesias) and PD symptoms in…
In 2013 the Boston Scientific VERCISE System has obtained regulatory approval for use in the European Union, CE mark was granted for the treatment of intractable primary and secondary dystonia.The objective of the study is to compile characteristics…
To sequence the GBA1 gene in Parkinson*s disease patients to identify possible participants for a possible future phase 1 trial. The gene will be described as wildtype (WT) or containing a mutation (GBA+); with record of the specific mutation. To…
The aims of this study are to investigate:1. How and when neurologists communicate the diagnosis of PD in diagnostic and post-diagnostic consultations, particularly focusing on timing, content, communication style and the impact of neurologist…
We aim to develop three cognitive profiles to assess FTDr in HD patients; 1) Fit to drive, 2) No longer fit to drive, and 3) Dubious fit to drive and no longer fit to drive. The profiles will be determined with classic neuropsychological tests,…
To assess the local and systemic safety and tolerability of ABBV-951 delivered as a CSCI for 24 hours daily for up to 52 weeks.
To unravel the cerebral mechanisms of re-emergent postural tremor in PD and understand to what extent these mechanisms overlap with those involved in resting tremor. A secondary objective is to understand how cerebral tremor-related mechanisms…
To investigate whether peripheral nerve ultrasound and DRG MRI can be used as reliable diagnostic and monitoring biomarkers of peripheral nervous system involvement in FA. Specifically, we will examine: 1) Whether conventional peripheral nerve…
The primary goal of this phase 0 study is to assess the variability of mitochondrial function measurements in healthy volunteers and PD patients.
Collecting blood samples of healthy volunteers (n=650) which can serve as a reference for the Personalized Parkinson Project.
Hypothesis: implementation of individualized, integrated 7 Tesla MRI and MEG brain networks can increase the effectiveness of DBS by improving motor symptoms and quality of life in patients with Parkinson's disease and essential tremor.…
Primary Objective: To identify disease (Parkinson*s disease) specific alterations in neural control of breathing by using respiratory neurophysiological techniques.
The aim of this study is to develop and validate this much-needed Parkinson*s Disease-specific rating scale; the so-called *Movement Disorders Society Rating Scale: Postural Instability and Gait Difficulties (PIGD)*. This PIGD rating scale assesses…
The primary objective is to investigate whether Parkinson*s patients are able to produce an optimal inhalation technique for the Cyclops® inhaler in their home situation after first and second inhalation instruction. The secondary objective is to…
This study will evaluate the long-term safety and tolerability of RO7234292 in patients with HD. In addition, the study will obtain long-term data on the efficacy, immunogenicity, exposure, and biomarkers of RO7234292. Specific objectives and…