48 results
To explore the safety, tolerability and the pharmacokinetic profile of 2-IB when given on top of therapeutic hypothermia.
To assess fidelity (quality), dose delivered (completeness), dose received (exposure and satisfaction), recruitment and context of two newly developed upper limb home-based training programs, i.e. one based on implicit strategies and one based on…
We aim to conduct a five year follow-up amongst the X-ALD carriers and assess their current symptomatic and biochemical status. This data will provide new insights in the progression of the disease in carriers. Moreover we would like to validate a…
To determine the feasibility of rs-fMRI in neonates undergoing a planned diagnostic MRI session following perinatal asphyxia. To assess intra-session reproducibility (test-retest reliability) of the rs-fMRI technique in neonates with asphyxia.
In this study one of the goals is to compare 7 tesla MRI with 3 tesla MRI in terms of lesion detection in epilepsy patients and depiction of specific dysplasia-related imaging characteristics. Furthermore, resected tissue will be scanned ex-vivo at…
1. Normalization of the abnormal serum TH parameters and thereby improving the clinical condition of the AHDS patients2. Observation of changes in cognitive and motor function.
To assess whether a higher prophylactic platelet transfusion threshold is superior to the lower thresholds in reducing the proportion of patients who experience a major bleed or death up to study day 28.
Primary objective is to assess the reliability and assess the reliability and construct validity of the Repetitive Movement Test (RMT) as a measure of spasticity in children with CP scheduled for ITB treatment, between 6-18 year.
To evaluate the long-term effects of early intervention in high-risk infants on the basis of the VIP-project.
To increase to knowledge of how adults with OBPL function, this research will be done with de next researchquestion: what iare the lengterm consequences of OBPL among adults? These questions are being adressed to with fhe ICF structure:- body…
The aim of the trial is to obtain data on the optimal dose, feasibility and pharmacokinetics of bumetanide when given as an add-on treatment for seizures in full term babies with hypoxic ischemic encephalopathy (HIE). Bumetanide will be given in a…
The aim of this research is to study the MRI-sequence with the best parameter settings for the most optimal image quality to visualize the sacral plexus and its branching nerves. Diffusion-weighted imaging, diffusion tensor imaging, 3D-GE-MEDIC and…
The primary objective of this explorative study is to evaluate the training effect on the upper extremity function of the (most) affected arm in unilateral activity, in children with unilateral and bilateral spastic Cerebral Palsy using the WiiTM…
The determination of the energy expenditure in wheelchair-bound children in rest, during daily activities, and during therapeutic horseback riding.
In this investigation we want to determine if stimulation of the nerve on each side of the neck that leads to the muscles that make the shoudlers shrug is possible in babies. This can possibly prevent a birth lesion of the barchial plexus in the…
The aim of this study is to visualize the cervical roots and brachial plexus in neonates reliably and reproducable.
Applicability of fetal brain imaging techniques for clinical purposes.
Optimizing orthotic management in children with cerebral palsy to improve mobility and participation
The primary objective of this study is to evaluate AFO efficacy in children with spastic CP using outcome measures related to ICF the components of *body functions and structures* and *activities and participation*. The secondary aim is to identify…
To study if, how, and to what extent, cortical reorganization occurs in children with unilateral Cerebral Palsy after mCIMT.
to describe neurophysiological characteristics of *writhing* and *fidgety* GMs in typically developing young infants by means of multiple surface EMG recordings and kinematics.