71 results
During this study it will be investigated what the effect is of multiple doses of CBD on the absorption and elimination from the body (this is called pharmacokinetics) of clobazam, stiripentol or valproate. It will also be investigated what the…
Distinguishing frontal lobe epilepsy from ADHD in terms of working memory.
The first goal of the present study is to elucidate the network topology of the MTL on both large-scale and micro-scale levels with the aim of further understanding epilepsy related changes to the network structure. Additionally we will also use the…
Primary Objective: - To gain insight on the underlying mechanisms of the variability of the response to ATN-DBS in patients with AED refractory epilepsySecondary Objective(s): - To gain insight in the neurophysiology of the anterior thalamic nucleus…
The objective of the study is to investigate if it is possible to predict the clinical outcome of a patient with SCN1A related epilepsy based on the findings of advanced genotyping. We aim to answer the following questions:1. Can clinical outcome in…
The primary objective of this trial are to assess the clinical usefulness (in terms of sensitivity and positive predictive value of 1. Combined heart rate and movement detection2. And the added value of video and audio detection in a population of…
To evaluate the long-term safety and tolerability of pregabalin in pediatric subjects 1 month through 16 years of age with partial onset seizures and pediatric and adult subjects 5 to 65 years of age with (PGTC) seizures.
Recently, population PK/PD modeling and simulation studies have enabled the development of evidence-based individualized dosing schemes for children with a limited number of subjects, thus improving drug safety and efficacy. The application of PK/PD…
Primary objective of this study is to improve identification of epileptic HFOs in EEG and MEG, by comparing them to HFOs in corticography. Secondary objectives are to study the predictive value of non-invasively recorded HFOs for disease activity…
To evaluate the long term safety and tolerability of GWP42003-P, as adjunctive treatment, in children and adults with inadequately controlled DS or LGS.All Patients:To evaluate the effect of GWP42003-P, as adjunctive treatment, on:* Quality of life…
Primary objective:The primary objective of this study is to evaluate the effect of LCM 200mg bid on the single dose PK and PD of a single warfarin 25mg dose.Secondary objective:The secondary objective of this study is to monitor the safety and…
Primary objective:To assess the two-year prevalence and incidence of clinical relevant arrhythmias in drug-resistant epilepsy.Secondary objective:To assess whether the recorded cardiac arrhythmias are related to epileptic seizures (subjectively from…
Pilot study on additional value of 7T as compared to 3T MRI
Evaluation of the efficacy and tolerability of adding verapamil to the antiepileptic drug regimen in patients who did not become seizure free on carbamazepine.
The primary objective of this study is to develop reliable signal analyzing methods for the monitoring of brain function in adult patients at risk for deterioration of brain function, (non)convulsive seizures or cerebral ischemia. The methods will…
Primary:- to determine the excretion balance and the PK of total radioactivity in 6 healthy male subjects following a single oral dose of UCB0942Secondary:- to identify and quantify metabolites of UCB0942- to gain further information on the PK,…
Our overall aim is to create a cost effective non-invasive method of pre-surgical assessment of language and memory function using MEG scanning. We propose a research project with the key objective to evaluate the effectiveness of a Dutch…
(1) Identification of novel loci and genes in which mutations are responsible for the development of inherited epileptic syndromes. (2) Establishing genotype-phenotype correlations; defining the yield of mutation screenings in specific patient…
Objective: To investigate active and resting state networks and other MR parameters in patients with epilepsy and to determine the possible influence of anti-epileptic drugs use.
Because the ketogenic diet has a large impact on daily life of both patient and parents/caretakers, it would be a great improvement if one would be able to predict the effectiveness at a much earlier stage. We hope to be able to trace mechanisms by…