63 results
To investigate in an unselected memory clinic sample, the clinical value of 18F]FBB PET in terms of1. change in diagnosis;2. change in level of confidence of diagnosis;3. impact on patient healthcare management.
1) Is e-COGRAT usable within the ABI population?2) What are the patients* experiences with e-COGRAT?3) What are the therapists* experiences with e-COGRAT?4) What changes in the e-COGRAT are necessary?5) Does this pilot with e-COGRAT show a decline…
The main objective of this study is to find (epi)genetic markers including SNPs/haplotypes, DNA methylation and RNA expression correlating with cognitive decline in clinical patients with Mild Cognitive Impairment (MCI) and Subjective Cognitive…
The current study is part of a larger project that aims at identifying genetic profiles that render subject vulnerable to pronounced memory decline at old age. This part of the project will assess cognitive functions in three different age cohorts…
Previous studies have suggested an association between FD and cognitive impairment but these were flawed either by lack of power, used variable assessment of cognitive functioning and/or merged results of different phenotypes and sexes. It is of…
A. To gain more knowledge about the prevalence of TBI in male prisoners in the PPC and the relationship of TBI with violent crime and aggression. We expect that TBI is more common in violent offenders than in non-violent offenders. More specific, we…
To study the longitudinal dynamics of blood biomarkers, including NfL, in patients with frontotemporal dementia.
To determine the relative bioavailability of pramipexole 4.5 mg tablets vs. 4.5 mg Sifrol in healthy subjects after up-titration.
The present study will examine how young-onset-dementia patients and their families can be supported in their home environment as long as possible and institutionalisation can be delayed. For this the functioning and care needs of young-onset-…
The most important objective of this study is the validation of various examination procedure to assess fitness to drive in older persons with cognitive impairments. The assessment procedure comprises nosological dementia diagnoses (e.g. AD, FTD) ,…
The purpose of this study is to examine whether walking ability and plantar flexor strength of young children with CP who follow functional power training improve more compared to usual care.
1) To determine if microinfarcts can be detected in the brain with 7T MRI in AD patients2) To determine the prevalence and number of cerebral microbleeds on 7T MRI in patients with AD and to relate these lesions to cognition and to the vascular risk…
What are the long-term consequences of prenatal exposure to cannabis and nicotine on the brain development of 6-year old children?
The main objective of this study is to characterize the flow of information in the fronto-parietal network during the simulation of movements using intracranial EEG recordings. In the characterization we will pinpoint the neuronal (sub)regions of…
* To implement a standardised MRI acquisition protocol in multiple centres across Europe (Part A).* To identify and evaluate new biomarkers of disease progression in patients with amnestic MCI by collecting biochemical, neuroimaging,…
The primary objective is to evaluate the presence of brain damage (defined by white matter lesions (WMLs) or cerebral atrophy or deviations at neuropsychological examination (NPE)) among adults with tetralogy of Fallot (TOF). The secondary objective…
The general objective is to validate and assess the clinical and economic added-value of a) innovative diagnostic tests developed in WP1 (PET tracers), WP2 (ultra high field MRI) and WP3 (CSF), and b) other emerging diagnostic tests for Alzheimer…
The first (primary) objective (study 1) is to examine 1a) risk factors for volume loss in the entorhinal cortex and compare these with risk factors for volume loss in the rest of the hippocampus at 1.5T MRI over 7 years of follow-up; and to examine…
To assess the impact of OH on cerebral perfusion and function in severe OH in AF (n=10) and healthy controls (n=10).
Primary objective: To determine whether the short-term neurological outcome of surviving children diagnosed with prenatally diagnosed ventriculomegaly is associated with the extent of VM before birth.Second objective: To determine whether the…