24 results
In this study the test characteristics of the early structural ultrasound examination (SUE) (at 13-14 weeks) will be evaluated and compared the those of the standard SUE/AUE at 20 weeks. Also, the amount of (in-)conclusive examinations and the…
With this study we want to determine the concentration lidocaine in newborn after partus using an episiotomy in relation to the concentration in mother. Our secondary objectives are to look at the relation between the degree of transmission of…
The main goal of this study is to examine the clinical applicability of the Monica AN24*, for the use of this device in the LUMC for prolonged CTG-registrations in high risk pregnancies and particularly in monitoring fetal cardiac arrhythmias. The…
The focus of this study is to get more insight in the pathophysiology of IUGR. The main goal is to investigate the applicability of STIC in determining fetal cardiac function in IUGR.
Developing a non-invasive test for detection of trisomy 21,13 orr 18 in the unborn fetusDeveloping a standardised protocol, inclusive quality criteria for the use of massive parallel sequencing of celfree fetal DNA in maternal plasmaOptimalising…
Evaluate the potential of these new parameters to identify small-for-gestational-age fetuses at risk of adverse outcome.
Primary objective: To determine whether the short-term neurological outcome of surviving children diagnosed with prenatally diagnosed ventriculomegaly is associated with the extent of VM before birth.Second objective: To determine whether the…
The aim of this study is to investigate whether it is possible to improve genetic diagnostic testing in case of fetal abnormalities and a normal karyotype. We are interested in the relevance of the additional genetic testing.We wish to study the…
We will investigate the feasibility of using STIC technology to evaluate the fetal cardiac anatomy in different stages of gestation. Further we will investigate the fetal cardiac function using STIC technology.
Identify, in the heavily RBC alloimmunized population of females after HDN treatment whether particular MHC class II alleles are associated with presence or absence of particular RBC immunization. The second aim of this study is to determine the…
The objective of the study is to investigate the long-termeffects of lithium on the development of children who are exposed to lithium during pregnancy.
This study aims to validate NI-fECG monitoring as an accurate and reliable monitoring technique for FHR, MHR and UA surveillance during labour. The aim of this validation is to work towards clinical implementation of NI-fECG monitoring.
This pilot study aims to explore the possible technical and practical problems that may be encountered when intrapartum NI-fECG monitoring is performed (PF2 study). The results of this pilot study will be the basis for a larger validation study…
The main objective is to pinpoint the biological pathways that set long-term risk of CVD and NDI when epigenetically disturbed during fetal development by (1) establishing a longitudinal cohort of MC twins, (2) defining epigenetic alterations…
To determine the concentration of belimumab in blood, saliva and seminal fluid in patients with SLE, treated with intravenous or subcutaneous belimumab.
To evaluate the long-term neurodevelopmental outcome in two groups of children with FNAIT. First, children with unanticipated disease *index cases* that were born without maternal IVIg administration during pregnancy. Second, children with…
Nemo Healthcare B.V. recently developed a new technique for monitoring the unborn baby. This technique is already widely used in unborn babies over 37 weeks of gestational age. The purpose of this study is to examine if that new technique is also…
The FAST Therapy Trial is a prospective trial of patients with a new diagnosis of fetal SVA aimed to compare the impact of different perinatal treatment strategies from the time of SVA diagnosis to birth or death1) The primary outcome will be the…
This study evaluates the impact of the various outcomes of prenatal exome sequencing (definitive diagnosis, probable diagnosis and incidental findings) on clinical decision making and on parental psychological wellbeing, compared between different…
We aim to investigate how chromosomal mosaicism affects development of the different embryonic and extra-embryonic tissues of the peri-implantation blastocyst and early post-implantation embryo to understand why some mosaic embryos can continue…