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The correlation between culture of the nasopharyngeal swab, the nose swab, swab from a handkerchief and a handkerchief directly in children with an upper respiratory tract infection

The objective is determine the correlation between the outcome of the cultures of the nasopharyngeal swab, the nose swab, the swab from a handkerchief and the handkerchief.

An open-label, two period study to determine the excretion balance and pharmacokinetics of 14C-GSK573719, administered as single dose of an oral solution and an intravenous infusion, to
healthy male adults

The purpose of the study is to investigate how quickly and to what extent GSK573719 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). The compound to be administered will be labeled…

Gene expression during ciliagenesis: Towards a novel candidate gene list for Primary Ciliary Dyskinesia

We aim to assess gene expression patterns in cilia-producing cells from healthy controls to develop a candidate gene list for PCD.

Advanced understanding of Staphylococcus aureus and Pseudomonas aeruginosa Infections in EuRopE * Intensive Care Units (ICU)

To estimate the incidence of S. aureus and P. aeruginosa ICU pneumonia, especially VAP, and to assess its association with patient-related and contextual factors, e.g. colonization status, serum antibody levels against S. aureus alpha toxin [AT],…

The use of a point-of-care thoracic ultrasound protocol for hospital medical emergency teams

Concordance between MET diagnosis with and without the use of ultrasound with the chart review definitive diagnosis will be studied. Also other secondary endpoints will be evaluated.

Microbiological etiology of community acquired pneumonia in immunocompromised adults.

Objective of the study is to quantify the microbiological etiology in immunocompromised patients, at least 18 years of age, with CAP needing hospitalization. And to determine the severity, antibiotic use and outcome of CAP in immunocompromised…

Relation between biomarkers and new radiographic abnormalities in patients hospitalized with Community Acquired Pneumonia

1. To assess the incidence of pulmonary infiltrates by means of low dose CT-scan in patients with a high clinical suspicion of CAP but with a normal chest x-ray 2. The levels of biomarkers (CRP, PCT, White blood cell count) will be compared to the…

Clinical value of ultra-low dose computed tomography compared to chest X-ray investigations in diagnosing pulmonary pathology

1. To assess the clinical value of ULDCT as compared to CXR examinations for diagnosing pulmonary pathology.2. To identify patient groups or indications that may benefit by replacing CXR by ULDCT examination. 3. To analyze the effect of…

An Open-Label Safety Extension Study to a Multicenter Study of Liposomal Amikacin for Inhalation (LAI) in Adult Patients with Nontuberculous Mycobacterial (NTM) Lung Infections caused by Mycobacterium avium complex (MAC) That are Refractory to Treatment

Primary Objective To evaluate long term safety and tolerability of LAI (590 mg) administered once daily (QD) for up to 12 months in subjects who were refractory to standard multi-drug treatment and failed to convert in Study INS-212. Secondary…

An exploratory study to assess the RSV titer in healthy volunteers as guidance for the main study

To determine pre-existing virus neutralization titer levels against RSV in a general healthy population (immunogenicity is a secondary study objective (proof-of concept) in the main phase I study).

Nebulising Amoxicillin-Clavulanic Acid in Patients with COPD (NACAP)

To investigate whether inhalation of nebulised amoxicillin clavulanic acid is effective in reaching amoxicillin sputum levels >= MIC 90 in patient with an exacerbation of COPD.

Clinical course and burden of disease of lower respiratory tract infections in
primary care

1. To evaluate the burden of disease of CAP and other LRTI in elderly in primary care in terms of duration of symptoms, number of hospitalization and mortality, and number of complications.2. To evaluate the burden of disease of CAP and other LRTI…

The effect of severe respiratory syncytial virus (RSV) lower respiratory tract infections in mechanically ventilated infants younger than 12 months of age on recurrent wheezing and lung function

The primary objective is a) to study the occurrence of recurrent wheezing following hospitalisation for severe RSV LRTD, and to study the differences in occurrence between ventilated and non-ventilated infants, and ) to study differences in lung…

Reproducibility of a 6-minute cycle ergometer test protocol in patients with COPD.

The objective of this study is to evaluate the reproducibility (CV) of a 6-minute cycle exercise performance test in patients with COPD.

Childhood study on respiratory pathogens from induced sputum

To determine the effectiveness of sputum induction in retrieving good quality sputum, identifying bacterial and viral pathogens in lower respiratory tract infections and determine the practical applicability of sputum induction in general pediatric…

Lung inflammation and injury during mechanical ventilation for respiratory syncytial virus induced respiratory failure in infancy

The primary objective is to study the level and time course of lung inflammation and lung injury of ventilated infants with RSV LRTD. Secondary objective include studying the correlation between the level and time course of lung inflammation and…

Rapid diagnosis of respiratory infections in primary healthcare: the PrimariPOC study.

The aim of this pilot study is to improve the diagnosis of respiratory infections in primary health care by evaluating the use of the mariPOC® (ArcDia International, Turku, Finland). The mariPOC® is a simple and rapid POCT for the detection of 9 of…

Early detection of pulmonary exacerbations in mucociliary clearance diseases: Molecular fingerprinting by exhaled breath and microbiome analysis

Objectives: The primary objective is to establish whether expiratory VOC analysis by electronic nose and GC-MS can: Ia) discriminate between patients (CF, PCD) with and without an exacerbation and Ib) discriminate between different microbial species…

Exploration of SpO2 probe for low resource settings

The primary objective of the study is to explore and compare the signal strength of different probes for measuring pulse oximetry signals on different body locations. The secondary objective of the study is comparing aspects of user experience (via…

An open-label, single-arm study to determine the excretion balance and metabolic disposition of [14C]GW642444 administered as a single dose of an oral solution to healthy male volunteers

Primary:To compare total radioactivity (drug-related material) in plasma relative to parent plasma GW642444 concentration following a single oral dose (200µg) of [14C]-GW642444 in healthy male subjects.To determine the rate and extent of excretion…