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Study 200170: A Rollover Study to Provide Continued Treatment with Eltrombopag

To provide continuing treatment with eltrombopag for subjects who are currently participating in a GSK sponsored investigational study of eltrombopag (parent study) and to collect long term safety data.

An Open-Label Study of the Safety and Efficacy of ReFacto AF in Previously Untreated Patients in Usual Care Settings

The primary objective is to evaluate the safety of ReFacto AF in previously untreated patients (no prior exposure to factor products or any blood products) of less than 6 years of age.

Immune Tolerance Induction study in patients with severe type A haemophilia
with inhibitor after failure of a previous induction of immune tolerance with
FVIII concentrates without Von Willebrand factor. (RESIST-EXPERIENCED)

Evaluate whether FVIII/VWF concentrates successfully induce immune tolerance in patients who have already experienced and failed immune tolerance induction with VWF-free FVIII concentrates.

Peroperatieve researchstudy with de ROTEM machine to hemostase of patients during aorta abdominalis aneurysm operation.

Objective of the study:Investigating with use of the classical coagulation tests on one hand and with the ROTEM on the other hand what is exactly becoming disturbed in the coagulaton because of bleeding during surgery of the aorta abdominalis,…

VON WILLEBRAND DISEASE PROPHYLAXIS NETWORK (vWD PN)
The VWD International Prophylaxis (VIP) Study

The objectives are to:A. Identify subjects with VWD who may benefit from prophylaxis by determining patterns of bleeding prior to evaluation for enrollmentB. Study the effect of prophylaxis on bleeding frequencyC. Establish optimal treatment…

SARS-CoV-2 vaccination response in patients with haematological
disease

3.2.1 Primary objectivesTo assess the efficacy in terms of Anti-SARS-COV-2 RBD antibody responses in patients diagnosed with and/or under treatment for a hematological disorder to SARS-CoV-2 vaccination.3.2.2 Secondary objectives 1. What is the…

Patient-guided dose reduction of tyrosine kinase inhibitors in chronic myeloid leukaemia (RODEO): a prospective, multicentre, single-arm study

Primary: To assess the proportion of patients with intervention failure at 12 months after dose reduction, defined as patients who have restarted their initial dose due to (expected) loss of major molecular response.

Dabigatran trough levels in elderly patients: are these increased, and to what extent? A pilot study.

Objective of the study is to measure dabigatran trough levels, percentage of dabigatran glucuronidation, and diluted thrombin time, to test whether these levels are different in elderly patients.

Stop TPO-receptor agonist in ITP Patients

Find/confirm percentage of remission after discontinuing TPO-RA in persistent and chronic ITP patients.

The Effect of Crizanlizumab on Cerebral Perfusion and Oxygenation in Sickle Cell Patients (CSEG101ANL01T)

To study the effect of crizanlizumab on the hemodynamics of the cerebral vasculature (CBF and CVR)

Advanced diagnostic management of suspected recurrent ipsilateral deep vein thrombosis of the leg with magnetic resonance direct thrombus imaging - The Theia study

The primary objective of the study is to assess the safety of a normal MRDTI to rule out acute, recurrent ipsilateral proximal DVT in a prospective, multicenter, single-arm management (cohort) study.Secondary objectives are:1.To evaluate the safety…